Human Recombinant FABP6 protein (V2LY-0526-LY3983)

Name: Human Recombinant FABP6 protein
SKU: V2LY-0526-LY3983
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Protein Construction

This product is Human Recombinant FABP6 protein consist of Amino Acid: 1-128 and predicts a molecular mass of 14.4 kDa.

Molecule Mass

14.4 kDa

Sequence

Amino Acid: 1-128

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

fatty acid binding protein 6, ileal

Research Area

Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity).

In vitro binds to bile acids in the order: deoxycholic acid> cholic acid> chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated> glycine-conjugated> unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion (By similarity).
Isoform 2:
Essential for the survival of colon cancer cells to bile acid-induced apoptosis.

Biological Process

Lipid metabolic process Source: ProtInc
Lipid transport Source: UniProtKB-KW
Negative regulation of cell population proliferation Source: ProtInc

Cellular Location

Isoform 1: Cytoplasm; Membrane
Isoform 2: Cytoplasm. Localized close to nucleus on the apical side of both normal and neoplastic cells.

Lian, W., Wang, Z., Ma, Y., Tong, Y., Zhang, X., Jin, H., ... & Peng, M. (2022). FABP6 Expression Correlates with Immune Infiltration and Immunogenicity in Colorectal Cancer Cells. Journal of Immunology Research, 2022.

Habib, S. M., Zwicker, B. L., Wykes, L., & Agellon, L. B. (2021). Sexually dimorphic response of mice to the Western‐style diet caused by deficiency of fatty acid binding protein 6 (Fabp6). Physiological reports, 9(3), e14733.

Pai, F. C., Huang, H. W., Tsai, Y. L., Tsai, W. C., Cheng, Y. C., Chang, H. H., & Chen, Y. (2021). Inhibition of FABP6 Reduces Tumor Cell Invasion and Angiogenesis through the Decrease in MMP-2 and VEGF in Human Glioblastoma Cells. Cells, 10(10), 2782.

Zhang, Y., Zhao, X., Deng, L., Li, X., Wang, G., Li, Y., & Chen, M. (2019). High expression of FABP4 and FABP6 in patients with colorectal cancer. World Journal of Surgical Oncology, 17(1), 1-13.

Chen, X. Y., Yin, Y., Xi, J., Yuan, Y., Li, Y., Li, Q., ... & Tang, G. L. (2018). 11‐Aza‐artemisinin Derivatives Exhibit Anticancer Activities by Targeting the Fatty Acid Binding Protein 6 (FABP6). Chinese Journal of Chemistry, 36(12), 1197-1201.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human FABP6 ELISA Kit (CAT#: V2LY-0626-LY4610)

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Rabbit Anti-FABP6 Recombinant Antibody (CBXF-1854) (CAT#: V2LY-0825-LY1255)

Mouse Anti-FABP6 Recombinant Antibody (CBXF-2811) (CAT#: CBMAB-F3521-CQ)

Human FABP6 ELISA Kit (CAT#: V2LY-0626-LY4610)

Mouse Anti-FABP6 Recombinant Antibody (CBLG1-388) (CAT#: V2LY-0825-LY1252)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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