Mouse Anti-FABP6 Recombinant Antibody (CBXF-2811) (CBMAB-F3521-CQ)

Name: Mouse Anti-FABP6 Recombinant Antibody (CBXF-2811)
SKU: CBMAB-F3521-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-2811

Application

ELISA, WB

Immunogen

Full-length recombinant FABP6.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

fatty acid binding protein 6, ileal

Introduction

This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene.

Entrez Gene ID

2172

UniProt ID

P51161

Alternative Names

Fatty Acid Binding Protein 6; Fatty Acid Binding Protein 6, Ileal; Ileal Bile Acid Binding Protein; Illeal Lipid-Binding Protein; Ileal Lipid-Binding Protein; Intestinal 15 KDa Protein; Gastrotropin; I-BABP; I-15P;

Research Area

Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity).

In vitro binds to bile acids in the order: deoxycholic acid> cholic acid> chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated> glycine-conjugated> unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion (By similarity).
Isoform 2:
Essential for the survival of colon cancer cells to bile acid-induced apoptosis.

Biological Process

Lipid metabolic process Source: ProtInc
Lipid transport Source: UniProtKB-KW
Negative regulation of cell population proliferation Source: ProtInc

Cellular Location

Isoform 1: Cytoplasm; Membrane
Isoform 2: Cytoplasm. Localized close to nucleus on the apical side of both normal and neoplastic cells.

Lian, W., Wang, Z., Ma, Y., Tong, Y., Zhang, X., Jin, H., ... & Peng, M. (2022). FABP6 Expression Correlates with Immune Infiltration and Immunogenicity in Colorectal Cancer Cells. Journal of Immunology Research, 2022.

Habib, S. M., Zwicker, B. L., Wykes, L., & Agellon, L. B. (2021). Sexually dimorphic response of mice to the Western‐style diet caused by deficiency of fatty acid binding protein 6 (Fabp6). Physiological reports, 9(3), e14733.

Pai, F. C., Huang, H. W., Tsai, Y. L., Tsai, W. C., Cheng, Y. C., Chang, H. H., & Chen, Y. (2021). Inhibition of FABP6 Reduces Tumor Cell Invasion and Angiogenesis through the Decrease in MMP-2 and VEGF in Human Glioblastoma Cells. Cells, 10(10), 2782.

Zhang, Y., Zhao, X., Deng, L., Li, X., Wang, G., Li, Y., & Chen, M. (2019). High expression of FABP4 and FABP6 in patients with colorectal cancer. World Journal of Surgical Oncology, 17(1), 1-13.

Chen, X. Y., Yin, Y., Xi, J., Yuan, Y., Li, Y., Li, Q., ... & Tang, G. L. (2018). 11‐Aza‐artemisinin Derivatives Exhibit Anticancer Activities by Targeting the Fatty Acid Binding Protein 6 (FABP6). Chinese Journal of Chemistry, 36(12), 1197-1201.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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