FCAR

This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Full Name
Fc Fragment Of IgA Receptor
Research Area
Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.
Biological Process
Cellular response to granulocyte macrophage colony-stimulating factor stimulus Source: CAFA
Cellular response to interferon-alpha Source: CAFA
Cellular response to interferon-gamma Source: CAFA
Cellular response to interleukin-6 Source: CAFA
Cellular response to lipopolysaccharide Source: CAFA
Cellular response to tumor necrosis factor Source: CAFA
Fc receptor signaling pathway Source: CAFA
Immune response Source: ProtInc
Neutrophil activation Source: CAFA
Neutrophil mediated immunity Source: CAFA
Positive regulation of neutrophil apoptotic process Source: CAFA
Positive regulation of oxidative stress-induced cell death Source: CAFA
Cellular Location
Isoform A.1&A.2&A.3: Cell membrane
Isoform B: Secreted
Isoform B-delta-S2: Secreted
Topology
Extracellular: 22-227
Helical: 228-246
Cytoplasmic: 247-287
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Anti-FCAR antibodies

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Target: FCAR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6G3G3E7
Application*: E, F
Target: FCAR
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 6
Application*: E
Target: FCAR
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10K142
Application*: WB
Target: FCAR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10K141
Application*: F, IF
Target: FCAR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10K140
Application*: F
Target: FCAR
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: 013
Application*: E
Target: FCAR
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 002
Application*: EC
Target: FCAR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H1742
Application*: E, F, IP, WB
Target: FCAR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3201
Application*: F
Target: FCAR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4168
Application*: F
Target: FCAR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3665
Application*: F
Target: FCAR
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A59
Application*: F, C
Target: FCAR
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0760
Application*: F
Target: FCAR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2472
Application*: E, F
Target: FCAR
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-C2471
Application*: E
Target: FCAR
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-2659
Application*: EC
Target: FCAR
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: CBFYC-2658
Application*: E
Target: FCAR
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-2657
Application*: WB
Target: FCAR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2656
Application*: F, IF
Target: FCAR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0417
Application*: F
Target: FCAR
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: MIP68b
Application*: WB
Target: FCAR
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-0436
Application*: WB
Target: FCAR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0435
Application*: F, I
Target: FCAR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0434
Application*: F, IF, I
Target: FCAR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0433
Application*: F, IF
Target: FCAR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0429
Application*: E, F, IP, WB
Target: FCAR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2579
Application*: F
Target: FCAR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MIP8a
Application*: WB, F, E, IP
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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