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Mouse Anti-FCAR Recombinant Antibody (CBXF-0429) (CBMAB-F0369-CQ)

This product is a mouse antibody that recognizes FCAR. The antibody CBXF-0429 can be used for immunoassay techniques such as: ELISA, FC, IP, WB.
See all FCAR antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-0429
Antibody Isotype
IgG1
Application
ELISA, FC, IP, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.1% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fc Fragment Of IgA Receptor
Introduction
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Entrez Gene ID
UniProt ID
Alternative Names
Fc Fragment Of IgA Receptor; Fc Fragment Of IgA, Receptor For; CD89; Immunoglobulin Alpha Fc Receptor; Fc Alpha Receptor; FCAR Variant 14;
Research Area
Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.
Biological Process
Cellular response to granulocyte macrophage colony-stimulating factor stimulus Source: CAFA
Cellular response to interferon-alpha Source: CAFA
Cellular response to interferon-gamma Source: CAFA
Cellular response to interleukin-6 Source: CAFA
Cellular response to lipopolysaccharide Source: CAFA
Cellular response to tumor necrosis factor Source: CAFA
Fc receptor signaling pathway Source: CAFA
Immune response Source: ProtInc
Neutrophil activation Source: CAFA
Neutrophil mediated immunity Source: CAFA
Positive regulation of neutrophil apoptotic process Source: CAFA
Positive regulation of oxidative stress-induced cell death Source: CAFA
Cellular Location
Isoform A.1&A.2&A.3: Cell membrane
Isoform B: Secreted
Isoform B-delta-S2: Secreted
Topology
Extracellular: 22-227
Helical: 228-246
Cytoplasmic: 247-287
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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