FCER2
The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Full Name
Fc Fragment Of IgE Receptor II
Research Area
Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
Biological Process
Positive regulation of humoral immune response mediated by circulating immunoglobulin Source: Ensembl
Positive regulation of killing of cells of other organism Source: BHF-UCL
Positive regulation of nitric-oxide synthase activity Source: BHF-UCL
Positive regulation of nitric-oxide synthase biosynthetic process Source: BHF-UCL
Positive regulation of killing of cells of other organism Source: BHF-UCL
Positive regulation of nitric-oxide synthase activity Source: BHF-UCL
Positive regulation of nitric-oxide synthase biosynthetic process Source: BHF-UCL
Cellular Location
Cell membrane; Cell membrane; Secreted. Also exists as a soluble excreted form, sCD23.
Topology
Cytoplasmic: 1-21
Helical: 22-47
Extracellular: 48-321
Helical: 22-47
Extracellular: 48-321
PTM
N- and O-glycosylated.
The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding.
The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding.
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Anti-FCER2 antibodies
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CompareTarget: FCER2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-3668
Application*: E, P
Target: FCER2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6
Application*: F
Target: FCER2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-C2480
Application*: P
Target: FCER2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2476
Application*: F
Target: FCER2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYC-0021
Application*: IP, P, IF, F
Target: FCER2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 22
Application*: WB, IP, IF, E, P
Target: FCER2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 527
Application*: F, IF, P
Target: FCER2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 223
Application*: E, WB
Target: FCER2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 336
Application*: IH, IF
Target: FCER2
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: 18
Application*: E, F, N
Target: FCER2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Horse
Clone: 96
Application*: WB
Target: FCER2
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2334
Application*: F
Target: FCER2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-0447
Application*: F, IF, IH
Target: FCER2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: C3466
Application*: P
Target: FCER2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-C2479
Application*: E
Target: FCER2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 7
Application*: E
Target: FCER2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 011
Application*: F, IF
Target: FCER2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: F2985
Application*: IF, P
Target: FCER2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 11H7
Application*: E, WB
Target: FCER2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 12C2
Application*: E, IH
Target: FCER2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT288
Application*: F, E
Target: FCER2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBT289
Application*: WB
Target: FCER2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBT290
Application*: IF, IC, P
Target: FCER2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2047
Application*: F
Target: FCER2
Specificity: Human
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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