FCER2

The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

Fc Fragment Of IgE Receptor II

Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

Positive regulation of humoral immune response mediated by circulating immunoglobulin Source: Ensembl
Positive regulation of killing of cells of other organism Source: BHF-UCL
Positive regulation of nitric-oxide synthase activity Source: BHF-UCL
Positive regulation of nitric-oxide synthase biosynthetic process Source: BHF-UCL

Cell membrane; Cell membrane; Secreted. Also exists as a soluble excreted form, sCD23.

Cytoplasmic: 1-21
Helical: 22-47
Extracellular: 48-321

N- and O-glycosylated.
The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding.