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Mouse Anti-FCER2 Recombinant Antibody (CBYY-C2480) (CBMAB-C3920-YY)

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Datasheet
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
CBYY-C2480
Application
ELISA, WB
Immunogen
NS0-derived recombinant human CD23 extracellular domain, UniProt # P06734
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein G purified
Preservative
50% glycerol, PBS, 5% trehalose
Concentration
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Fc Fragment Of IgE Receptor II
Entrez Gene ID
2208
UniProt ID
P06734
Alternative Names
Fucosyltransferase 4; Galactoside 3-L-Fucosyltransferase; Alpha (1,3) Fucosyltransferase, Myeloid-Specific; ELAM-1 Ligand Fucosyltransferase; ELAM Ligand Fucosyltransferase; Fucosyltransferase IV; FUC-TIV; FucT-IV; FCT3A; ELFT; Stage-Specific Embryonic Antigen 1;
Research Area
Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
Biological Process
Positive regulation of humoral immune response mediated by circulating immunoglobulin Source: Ensembl
Positive regulation of killing of cells of other organism Source: BHF-UCL
Positive regulation of nitric-oxide synthase activity Source: BHF-UCL
Positive regulation of nitric-oxide synthase biosynthetic process Source: BHF-UCL
Cellular Location
Cell membrane; Cell membrane; Secreted. Also exists as a soluble excreted form, sCD23.
Topology
Cytoplasmic: 1-21
Helical: 22-47
Extracellular: 48-321
PTM
N- and O-glycosylated.
The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding.

Du, L., Chen, W., Li, C., Cui, Y., & He, Z. (2022). RNF144B stimulates the proliferation and inhibits the apoptosis of human spermatogonial stem cells via the FCER2/NOTCH2/HES1 pathway and its abnormality is associated with azoospermia. Journal of Cellular Physiology, 237(9), 3565-3577.

Aranda, C. J., Gonzalez‐Kozlova, E., Saunders, S. P., Fernandes‐Braga, W., Ota, M., Narayanan, S., ... & Lafaille, M. A. C. D. (2022). IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases. Allergy.

Soares, P., Fidler, K., Felton, J., Jones, C. J., Tavendale, R., Hövels, A., ... & Mukhopadhyay, S. (2021). An FCER2 polymorphism is associated with increased oral leukotriene receptor antagonists and allergic rhinitis prescribing. Clinical and experimental allergy, 51(8), 1089-1092.

Duong-Quy, S., Le-Thi-Minh, H., Nguyen-Thi-Bich, H., Pham-Thu, H., Thom, V. T., Pham-Thi-Hong, N., ... & Craig, T. J. (2020). Correlations between exhaled nitric oxide, rs28364072 polymorphism of FCER2 gene, asthma control, and inhaled corticosteroid responsiveness in children with asthma. Journal of breath research, 15(1), 016012.

Karimi, L., Vijverberg, S. J., Farzan, N., Ghanbari, M., Verhamme, K. M., & Maitland‐van der Zee, A. H. (2019). FCER2 T2206C variant associated with FENO levels in asthmatic children using inhaled corticosteroids: The PACMAN study. Clinical & Experimental Allergy, 49(11), 1429-1436.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

FCER2 Matched Antibody Pair (417) (CAT#: APMAB-417LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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