Mouse Anti-FCER2 Recombinant Antibody (
12C2) (V2LY-0725-LY22)

Name: Mouse Anti-FCER2 Recombinant Antibody (12C2)
SKU: V2LY-0725-LY22
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-FCER2 Recombinant Antibody (12C2) (V2LY-0725-LY22) in IHC

IHC staining of Human tonsil tissue paraffin-embedded, diluted at 1:200.

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

12C2

Application

ELISA, IHC

Immunogen

Synthetic Peptide.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

Application	Note
IHC	1:100-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, Glycerol

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Fc Fragment Of IgE Receptor II

Entrez Gene ID

2208

UniProt ID

P06734

Research Area

Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

Biological Process

Positive regulation of humoral immune response mediated by circulating immunoglobulin Source: Ensembl
Positive regulation of killing of cells of other organism Source: BHF-UCL
Positive regulation of nitric-oxide synthase activity Source: BHF-UCL
Positive regulation of nitric-oxide synthase biosynthetic process Source: BHF-UCL

Cellular Location

Cell membrane; Cell membrane; Secreted. Also exists as a soluble excreted form, sCD23.

Topology

Cytoplasmic: 1-21
Helical: 22-47
Extracellular: 48-321

PTM

N- and O-glycosylated.
The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding.

Du, L., Chen, W., Li, C., Cui, Y., & He, Z. (2022). RNF144B stimulates the proliferation and inhibits the apoptosis of human spermatogonial stem cells via the FCER2/NOTCH2/HES1 pathway and its abnormality is associated with azoospermia. Journal of Cellular Physiology, 237(9), 3565-3577.

Aranda, C. J., Gonzalez‐Kozlova, E., Saunders, S. P., Fernandes‐Braga, W., Ota, M., Narayanan, S., ... & Lafaille, M. A. C. D. (2022). IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases. Allergy.

Soares, P., Fidler, K., Felton, J., Jones, C. J., Tavendale, R., Hövels, A., ... & Mukhopadhyay, S. (2021). An FCER2 polymorphism is associated with increased oral leukotriene receptor antagonists and allergic rhinitis prescribing. Clinical and experimental allergy, 51(8), 1089-1092.

Duong-Quy, S., Le-Thi-Minh, H., Nguyen-Thi-Bich, H., Pham-Thu, H., Thom, V. T., Pham-Thi-Hong, N., ... & Craig, T. J. (2020). Correlations between exhaled nitric oxide, rs28364072 polymorphism of FCER2 gene, asthma control, and inhaled corticosteroid responsiveness in children with asthma. Journal of breath research, 15(1), 016012.

Karimi, L., Vijverberg, S. J., Farzan, N., Ghanbari, M., Verhamme, K. M., & Maitland‐van der Zee, A. H. (2019). FCER2 T2206C variant associated with FENO levels in asthmatic children using inhaled corticosteroids: The PACMAN study. Clinical & Experimental Allergy, 49(11), 1429-1436.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

FCER2 Matched Antibody Pair (417) (CAT#: APMAB-417LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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