FDX1

The product of this gene is a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to a terminal cytochrome P450. This particular oxidation/reduction system is found in steroidogenic tissues, and is involved with the synthesis of bile acid and vitamin D. In addition to the expressed gene at this chromosomal locus (11q22), there are pseudogenes located on chromosomes 20 and 21. This gene product has been identified in a number of different tissues but all forms have been shown to be identical and are not tissue specific. [provided by RefSeq]

ferredoxin 1

Essential for the synthesis of various steroid hormones (PubMed:20547883, PubMed:21636783).

Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis (PubMed:20547883, PubMed:21636783).

Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage (PubMed:20547883, PubMed:21636783).

Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity).

Cellular response to cAMP Source: Ensembl
Cellular response to forskolin Source: Ensembl
Cholesterol metabolic process Source: UniProtKB
Hormone biosynthetic process Source: UniProtKB
Steroid biosynthetic process Source: UniProtKB-KW

Mitochondrion matrix