FGF19
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008]
Full Name
Fibroblast Growth Factor 19
Research Area
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.
Biological Process
Animal organ morphogenesis Source: GO_Central
Cell differentiation Source: GO_Central
Fibroblast growth factor receptor signaling pathway Source: MGI
Negative regulation of bile acid biosynthetic process Source: UniProtKB
Negative regulation of gene expression Source: UniProtKB
Nervous system development Source: ProtInc
Positive regulation of cell population proliferation Source: MGI
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of gene expression Source: GO_Central
Positive regulation of glucose import Source: UniProtKB
Positive regulation of JNK cascade Source: UniProtKB
Positive regulation of protein phosphorylation Source: UniProtKB
Regulation of cell migration Source: GO_Central
Cell differentiation Source: GO_Central
Fibroblast growth factor receptor signaling pathway Source: MGI
Negative regulation of bile acid biosynthetic process Source: UniProtKB
Negative regulation of gene expression Source: UniProtKB
Nervous system development Source: ProtInc
Positive regulation of cell population proliferation Source: MGI
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of gene expression Source: GO_Central
Positive regulation of glucose import Source: UniProtKB
Positive regulation of JNK cascade Source: UniProtKB
Positive regulation of protein phosphorylation Source: UniProtKB
Regulation of cell migration Source: GO_Central
Cellular Location
Secreted
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Anti-FGF19 antibodies
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Target: FGF19
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 6
Application*: B, WB, E
Target: FGF19
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-1665
Application*: E, WB
Target: FGF19
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-0552
Application*: WB, IP, IF, E, P
Target: FGF19
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-0551
Application*: E
Target: FGF19
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-1993
Application*: WB, IP, IF, E, P
Target: FGF19
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0550
Application*: F
Target: FGF19
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-3309
Application*: WB, E, F, IH
Target: FGF19
Host: Human
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-3308
Application*: E, F
Target: FGF19
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 11H3
Application*: E, WB
Target: FGF19
Specificity: Human
Target: FGF19
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 36
Application*: IH, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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