FGF19

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008]
Full Name
Fibroblast Growth Factor 19
Research Area
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.
Biological Process
Animal organ morphogenesis Source: GO_Central
Cell differentiation Source: GO_Central
Fibroblast growth factor receptor signaling pathway Source: MGI
Negative regulation of bile acid biosynthetic process Source: UniProtKB
Negative regulation of gene expression Source: UniProtKB
Nervous system development Source: ProtInc
Positive regulation of cell population proliferation Source: MGI
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of gene expression Source: GO_Central
Positive regulation of glucose import Source: UniProtKB
Positive regulation of JNK cascade Source: UniProtKB
Positive regulation of protein phosphorylation Source: UniProtKB
Regulation of cell migration Source: GO_Central
Cellular Location
Secreted
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Anti-FGF19 antibodies

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Mouse Anti-FGF19 Recombinant Antibody (6) (CBMAB-0281CQ)

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Target: FGF19
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 6
Application*: B, WB, E
Functional Assay
Datasheet SDS

Mouse Anti-FGF19 Recombinant Antibody (CBXF-1665) (CBMAB-F4053-CQ)

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Target: FGF19
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-1665
Application*: E, WB
Datasheet SDS

Mouse Anti-FGF19 Recombinant Antibody (CBXF-0552) (CBMAB-F1444-CQ)

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Target: FGF19
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-0552
Application*: WB, IP, IF, E, P
Datasheet SDS

Rabbit Anti-FGF19 Recombinant Antibody (CBXF-0551) (CBMAB-F1390-CQ)

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Target: FGF19
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-0551
Application*: E
Datasheet SDS

Mouse Anti-FGF19 Recombinant Antibody (CBXF-1993) (CBMAB-F0715-CQ)

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Target: FGF19
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-1993
Application*: WB, IP, IF, E, P
Datasheet SDS

Human Anti-FGF19 Recombinant Antibody (CBXF-0550) (CBMAB-F0402-CQ)

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Target: FGF19
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0550
Application*: F
Datasheet SDS

Human Anti-FGF19 Recombinant Antibody (CBXF-3309) (CBMAB-F0216-CQ)

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Target: FGF19
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-3309
Application*: WB, E, F, IH
Functional Assay
Datasheet SDS

Human Anti-FGF19 Recombinant Antibody (CBXF-3308) (CBMAB-F0107-CQ)

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Target: FGF19
Host: Human
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-3308
Application*: E, F
Datasheet SDS

Human Recombinant FGF19 protein (V2LY-0526-LY4057)

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Target: FGF19
Expressed Host: E. coli
Sequence: Amino Acid: 27-216
Datasheet SDS

Rabbit Anti-FGF19 Recombinant Antibody (
11H3) (V2LY-0725-LY1219)

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Target: FGF19
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 11H3
Application*: E, WB
Datasheet SDS

FGF19 Matched Antibody Pair (431) (APMAB-431LY)

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Target: FGF19
Specificity: Human
Datasheet SDS

Mouse Anti-FGF19 Recombinant Antibody (36) (CBMAB-1253-YC)

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Target: FGF19
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 36
Application*: IH, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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