Mouse Anti-FGF19 Recombinant Antibody (FG98-6) (CBMAB-0281CQ)

Name: Mouse Anti-FGF19 Recombinant Antibody (FG98-6)
SKU: CBMAB-0281CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

FG98-6

Application

IHC-P, WB

Immunogen

Recombinant full length protein from Human FGF19

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Fibroblast Growth Factor 19

Introduction

Fibroblast growth factors (FGFs), such as FGF19, play important roles in multiple physiologic functions, including angiogenesis, mitogenesis, pattern formation, cellular differentiation, metabolic regulation, tissue repair, and oncogenesis (Nishimura et al., 1999). FGF19 is a member of a subfamily of FGFs that govern nutrient metabolism. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.

Entrez Gene ID

9965

UniProt ID

O95750

Alternative Names

Fibroblast Growth Factor 19; FGF-19

Research Area

Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.

Biological Process

Animal organ morphogenesis Source: GO_Central
Cell differentiation Source: GO_Central
Fibroblast growth factor receptor signaling pathway Source: MGI
Negative regulation of bile acid biosynthetic process Source: UniProtKB
Negative regulation of gene expression Source: UniProtKB
Nervous system development Source: ProtInc
Positive regulation of cell population proliferation Source: MGI
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of gene expression Source: GO_Central
Positive regulation of glucose import Source: UniProtKB
Positive regulation of JNK cascade Source: UniProtKB
Positive regulation of protein phosphorylation Source: UniProtKB
Regulation of cell migration Source: GO_Central

Cellular Location

Secreted

Chrysavgis, L., Giannakodimos, I., Chatzigeorgiou, A., Tziomalos, K., Papatheodoridis, G., & Cholongitas, E. (2022). The role of fibroblast growth factor 19 in the pathogenesis of nonalcoholic fatty liver disease. Expert Review of Gastroenterology & Hepatology, 16(9), 835-849.

Ursic-Bedoya, J., Chavey, C., Desandré, G., Meunier, L., Dupuy, A. M., Reyes, I. G. D., ... & Gregoire, D. (2022). Fibroblast growth factor 19 stimulates water intake. Molecular Metabolism, 60, 101483.

Liu, T., Tang, X., Cui, Y., Xiong, X., Xu, Y., Hu, S., ... & Wang, C. (2022). Fibroblast growth factor 19 improves LPS-induced lipid disorder and organ injury by regulating metabolomic characteristics in mice. Oxidative Medicine and Cellular Longevity, 2022.

Mohamed, G. A., Nashaat, E. H., Fawzy, H. M., & ElGhandour, A. M. (2022). Assessment of fibroblast growth factor 19 as a non-invasive serum marker for hepatocellular carcinoma. World Journal of Hepatology, 14(3), 623.

Chen, H., Li, J., Zhang, D., Zhou, X., & Xie, J. (2021). Role of the fibroblast growth factor 19 in the skeletal system. Life Sciences, 265, 118804.

Chen, Z., Jiang, L., Liang, L., Koral, K., Zhang, Q., Zhao, L., ... & Tao, J. (2021). The role of fibroblast growth factor 19 in hepatocellular carcinoma. The American Journal of Pathology, 191(7), 1180-1192.

Zhou, Y., Yang, L., Bo, C., Zhang, X., Zhang, J., & Li, Y. (2021). MicroRNA-9-3p Aggravates Cerebral Ischemia/Reperfusion Injury by Targeting Fibroblast Growth Factor 19 (FGF19) to Inactivate GSK-3β/Nrf2/ARE Signaling. Neuropsychiatric Disease and Treatment, 17, 1989.

Guo, A., Li, K., & Xiao, Q. (2020). Fibroblast growth factor 19 alleviates palmitic acid-induced mitochondrial dysfunction and oxidative stress via the AMPK/PGC-1α pathway in skeletal muscle. Biochemical and Biophysical Research Communications, 526(4), 1069-1076.

Maeda, T., Kanzaki, H., Chiba, T., Ao, J., Kanayama, K., Maruta, S., ... & Kato, N. (2019). Serum fibroblast growth factor 19 serves as a potential novel biomarker for hepatocellular carcinoma. BMC cancer, 19(1), 1-9.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

FGF19 Matched Antibody Pair (431) (CAT#: APMAB-431LY)

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Isotype control

For research use only. Not intended for any clinical use.

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