Rabbit Anti-FGF19 Recombinant Antibody (
11H3) (V2LY-0725-LY1219)

Name: Rabbit Anti-FGF19 Recombinant Antibody (11H3)
SKU: V2LY-0725-LY1219
Rating: 5 (1 reviews)

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Tested Data

Rabbit Anti-FGF19 Recombinant Antibody (11H3) (V2LY-0725-LY1219) in WB

Western Blot
Positive WB detected in: Ntera-2 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate, A549 whole cell lysate
All lanes: FGF19 antibody at 1:500
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 25 kDa
Observed band size: 36 kDa

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

11H3

Application

ELISA, WB

Immunogen

A synthesized peptide derived from human FGF19.

Host Species

Rabbit

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, glycerol

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Fibroblast Growth Factor 19

Entrez Gene ID

9965

UniProt ID

O95750

Research Area

Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.

Biological Process

Animal organ morphogenesis Source: GO_Central
Cell differentiation Source: GO_Central
Fibroblast growth factor receptor signaling pathway Source: MGI
Negative regulation of bile acid biosynthetic process Source: UniProtKB
Negative regulation of gene expression Source: UniProtKB
Nervous system development Source: ProtInc
Positive regulation of cell population proliferation Source: MGI
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of gene expression Source: GO_Central
Positive regulation of glucose import Source: UniProtKB
Positive regulation of JNK cascade Source: UniProtKB
Positive regulation of protein phosphorylation Source: UniProtKB
Regulation of cell migration Source: GO_Central

Cellular Location

Secreted

Chrysavgis, L., Giannakodimos, I., Chatzigeorgiou, A., Tziomalos, K., Papatheodoridis, G., & Cholongitas, E. (2022). The role of fibroblast growth factor 19 in the pathogenesis of nonalcoholic fatty liver disease. Expert Review of Gastroenterology & Hepatology, 16(9), 835-849.

Ursic-Bedoya, J., Chavey, C., Desandré, G., Meunier, L., Dupuy, A. M., Reyes, I. G. D., ... & Gregoire, D. (2022). Fibroblast growth factor 19 stimulates water intake. Molecular Metabolism, 60, 101483.

Liu, T., Tang, X., Cui, Y., Xiong, X., Xu, Y., Hu, S., ... & Wang, C. (2022). Fibroblast growth factor 19 improves LPS-induced lipid disorder and organ injury by regulating metabolomic characteristics in mice. Oxidative Medicine and Cellular Longevity, 2022.

Mohamed, G. A., Nashaat, E. H., Fawzy, H. M., & ElGhandour, A. M. (2022). Assessment of fibroblast growth factor 19 as a non-invasive serum marker for hepatocellular carcinoma. World Journal of Hepatology, 14(3), 623.

Chen, H., Li, J., Zhang, D., Zhou, X., & Xie, J. (2021). Role of the fibroblast growth factor 19 in the skeletal system. Life Sciences, 265, 118804.

Chen, Z., Jiang, L., Liang, L., Koral, K., Zhang, Q., Zhao, L., ... & Tao, J. (2021). The role of fibroblast growth factor 19 in hepatocellular carcinoma. The American Journal of Pathology, 191(7), 1180-1192.

Zhou, Y., Yang, L., Bo, C., Zhang, X., Zhang, J., & Li, Y. (2021). MicroRNA-9-3p Aggravates Cerebral Ischemia/Reperfusion Injury by Targeting Fibroblast Growth Factor 19 (FGF19) to Inactivate GSK-3β/Nrf2/ARE Signaling. Neuropsychiatric Disease and Treatment, 17, 1989.

Guo, A., Li, K., & Xiao, Q. (2020). Fibroblast growth factor 19 alleviates palmitic acid-induced mitochondrial dysfunction and oxidative stress via the AMPK/PGC-1α pathway in skeletal muscle. Biochemical and Biophysical Research Communications, 526(4), 1069-1076.

Maeda, T., Kanzaki, H., Chiba, T., Ao, J., Kanayama, K., Maruta, S., ... & Kato, N. (2019). Serum fibroblast growth factor 19 serves as a potential novel biomarker for hepatocellular carcinoma. BMC cancer, 19(1), 1-9.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

FGF19 Matched Antibody Pair (431) (CAT#: APMAB-431LY)

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Isotype control

For research use only. Not intended for any clinical use.

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