Sign in or Register

Keywords Search | Target Search

FKBP5

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

Full Name

FK506 Binding Protein 5

Function

Immunophilin protein with PPIase and co-chaperone activities (PubMed:11350175).

Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (PubMed:12538866).

Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:28147277).

Biological Process

Chaperone-mediated protein folding Source: UniProtKB
Protein folding Source: ProtInc
Protein peptidyl-prolyl isomerization Source: GO_Central
Response to bacterium Source: Ensembl

Cellular Location

Cytoplasm; Nucleus

PTM

Acetylation impairs ability to promote interaction between Akt/AKT1 and PHLPP1 (PubMed:28147277). Deacetylation by SIRT7 promotes interaction between Akt/AKT1 and PHLPP1, leading to suppress Akt/AKT1 activation (PubMed:28147277).

Anti-FKBP5 antibodies

Mouse Anti-FKBP5 Recombinant Antibody (3D10-1G11) (CBMAB-A2998-LY)

SDS

Target: FKBP5

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 3D10-1G11

Application*: WB, E

Mouse Anti-FKBP5 Recombinant Antibody (3D1-1B10) (CBMAB-A2999-LY)

SDS

Target: FKBP5

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 3D1-1B10

Application*: WB, E

Mouse Anti-FKBP5 Recombinant Antibody (4H7-1F12) (CBMAB-A3000-LY)

SDS

Target: FKBP5

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4H7-1F12

Application*: SE, E

Rabbit Anti-FKBP5 Recombinant Antibody (D5G2) (CBMAB-CP0712-LY)

SDS

Target: FKBP5

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey

Clone: D5G2

Application*: WB, IP

Rabbit Anti-FKBP5 Recombinant Antibody (CBXF-1228) (CBMAB-F0200-CQ)

SDS

Target: FKBP5

Host: Rabbit

Antibody Isotype: IgG

Specificity: Rat, Human

Clone: CBXF-1228

Application*: WB, IP, P, F, IF

Mouse Anti-FKBP5 Recombinant Antibody (Hi51B) (CBMAB-F0211-CQ)

SDS

Target: FKBP5

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Rabbit, Dog, Hamster

Clone: Hi51B

Application*: WB, IF

Mouse Anti-FKBP5 Recombinant Antibody (CBXF-0716) (CBMAB-F0434-CQ)

SDS

Target: FKBP5

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBXF-0716

Application*: E, IF, WB

Mouse Anti-FKBP5 Recombinant Antibody (CBXF-1973) (CBMAB-F0734-CQ)

SDS

Target: FKBP5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Chicken, Mouse, Rat

Clone: CBXF-1973

Application*: WB, IF

Mouse Anti-FKBP5 Recombinant Antibody (CBXF-3534) (CBMAB-F1045-CQ)

SDS

Target: FKBP5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-3534

Application*: WB, P, F

Rabbit Anti-FKBP5 Recombinant Antibody (CBXF-2241) (CBMAB-F1631-CQ)

SDS

Target: FKBP5

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBXF-2241

Application*: IF, WB

Rabbit Anti-FKBP5 Recombinant Antibody (CBXF-2064) (CBMAB-F2045-CQ)

SDS

Target: FKBP5

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey

Clone: CBXF-2064

Application*: WB, IP

Rat Anti-FKBP5 (AA 1-1457) Recombinant Antibody (CBXF-2645) (CBMAB-F3065-CQ)

SDS

Target: FKBP5

Host: Rat

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Rat

Clone: CBXF-2645

Application*: WB

Mouse Anti-FKBP5 Recombinant Antibody (CBXF-3053) (CBMAB-F3755-CQ)

SDS

Target: FKBP5

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBXF-3053

Application*: E, IF, WB

Mouse Anti-FKBP5 (AA 1-457) Recombinant Antibody (CBXF-3054) (CBMAB-F3756-CQ)

SDS

Target: FKBP5

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-3054

Application*: E, WB

Rabbit Anti-FKBP5 Recombinant Antibody (CBXF-2240) (CBMAB-F1628-CQ)

SDS

Target: FKBP5

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-2240

Application*: IF, WB

Mouse Anti-FKBP5 Recombinant Antibody (CBXF-0715) (CBMAB-F3186-CQ)

SDS

Target: FKBP5

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXF-0715

Application*: SE, E

Mouse Anti-FKBP5 Recombinant Antibody (CBXF-3347) (CBMAB-F4098-CQ)

SDS

Target: FKBP5

Host: Mouse

Antibody Isotype: IgG

Specificity: Dog, Hamster, Human, Mouse, Rabbit, Rat

Clone: CBXF-3347

Application*: WB

FKBP5 Matched Antibody Pair (447) (APMAB-447LY)

SDS

Target: FKBP5

Specificity: Human

FKBP5 Matched Antibody Pair (448) (APMAB-448LY)

SDS

Target: FKBP5

Specificity: Human

FKBP5 Matched Antibody Pair (449) (APMAB-449LY)

SDS

Target: FKBP5

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

Go to
Compare