Mouse Anti-FKBP5 Recombinant Antibody (CBXF-0715) (V2LY-0925-LY2095)

Name: Mouse Anti-FKBP5 Recombinant Antibody (CBXF-0715)
SKU: V2LY-0925-LY2095
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-0715

Application

ELISA, WB, IF

Immunogen

FKBP5 full-length recombinant protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

Application	Note
IF(ICC)	10 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

FK506 Binding Protein 5

Entrez Gene ID

2289

UniProt ID

Q13451

Function

Immunophilin protein with PPIase and co-chaperone activities (PubMed:11350175).

Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (PubMed:12538866).

Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:28147277).

Biological Process

Chaperone-mediated protein folding Source: UniProtKB
Protein folding Source: ProtInc
Protein peptidyl-prolyl isomerization Source: GO_Central
Response to bacterium Source: Ensembl

Cellular Location

Cytoplasm; Nucleus

PTM

Acetylation impairs ability to promote interaction between Akt/AKT1 and PHLPP1 (PubMed:28147277). Deacetylation by SIRT7 promotes interaction between Akt/AKT1 and PHLPP1, leading to suppress Akt/AKT1 activation (PubMed:28147277).

Kageyama, K., Iwasaki, Y., Watanuki, Y., Niioka, K., & Daimon, M. (2021). Differential effects of Fkbp4 and Fkbp5 on regulation of the proopiomelanocortin gene in murine AtT-20 corticotroph cells. International Journal of Molecular Sciences, 22(11), 5724.

Bierer, L. M., Bader, H. N., Daskalakis, N. P., Lehrner, A., Provençal, N., Wiechmann, T., ... & Yehuda, R. (2020). Intergenerational effects of maternal holocaust exposure on FKBP5 methylation. American Journal of Psychiatry, 177(8), 744-753.

Zannas, A. S., Jia, M., Hafner, K., Baumert, J., Wiechmann, T., Pape, J. C., ... & Binder, E. B. (2019). Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-κB–driven inflammation and cardiovascular risk. Proceedings of the National Academy of Sciences, 116(23), 11370-11379.

Klinger-König, J., Hertel, J., Van der Auwera, S., Frenzel, S., Pfeiffer, L., Waldenberger, M., ... & Grabe, H. J. (2019). Methylation of the FKBP5 gene in association with FKBP5 genotypes, childhood maltreatment and depression. Neuropsychopharmacology, 44(5), 930-938.

Hawn, S. E., Sheerin, C. M., Lind, M. J., Hicks, T. A., Marraccini, M. E., Bountress, K., ... & Amstadter, A. B. (2019). GxE effects of FKBP5 and traumatic life events on PTSD: A meta-analysis. Journal of Affective Disorders, 243, 455-462.

Roberts, S., Keers, R., Breen, G., Coleman, J. R., Jöhren, P., Kepa, A., ... & Wong, C. C. (2019). DNA methylation of FKBP5 and response to exposure‐based psychological therapy. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 180(2), 150-158.

Ising, M., Maccarrone, G., Brückl, T., Scheuer, S., Hennings, J., Holsboer, F., ... & Lucae, S. (2019). FKBP5 gene expression predicts antidepressant treatment outcome in depression. International journal of molecular sciences, 20(3), 485.

Wang, Q., Shelton, R. C., & Dwivedi, Y. (2018). Interaction between early-life stress and FKBP5 gene variants in major depressive disorder and post-traumatic stress disorder: A systematic review and meta-analysis. Journal of affective disorders, 225, 422-428.

Matosin, N., Halldorsdottir, T., & Binder, E. B. (2018). Understanding the molecular mechanisms underpinning gene by environment interactions in psychiatric disorders: the FKBP5 model. Biological psychiatry, 83(10), 821-830.

Tozzi, L., Farrell, C., Booij, L., Doolin, K., Nemoda, Z., Szyf, M., ... & Frodl, T. (2018). Epigenetic changes of FKBP5 as a link connecting genetic and environmental risk factors with structural and functional brain changes in major depression. Neuropsychopharmacology, 43(5), 1138-1145.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

FKBP5 Matched Antibody Pair (447) (CAT#: APMAB-447LY)

FKBP5 Matched Antibody Pair (448) (CAT#: APMAB-448LY)

FKBP5 Matched Antibody Pair (449) (CAT#: APMAB-449LY)

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Rat Anti-FKBP5 Recombinant Antibody (CBXF-2645) (CAT#: V2LY-0925-LY2094)

Rabbit Anti-FKBP5 Recombinant Antibody (CBXF-1228) (CAT#: V2LY-0925-LY2086)

Mouse Anti-FKBP5 Recombinant Antibody (CBXF-1973) (CAT#: V2LY-0925-LY2089)

FKBP5 Matched Antibody Pair (449) (CAT#: APMAB-449LY)

FKBP5 Matched Antibody Pair (447) (CAT#: APMAB-447LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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