Foxh1

FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT.

Full Name

forkhead box H1

Function

Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).

Biological Process

Aorta morphogenesis Source: Ensembl
Axial mesoderm development Source: Ensembl
Cardiac right ventricle morphogenesis Source: Ensembl
Cellular response to cytokine stimulus Source: UniProtKB
Embryonic heart tube anterior/posterior pattern specification Source: Ensembl
Heart looping Source: Ensembl
Negative regulation of androgen receptor signaling pathway Source: BHF-UCL
Negative regulation of DNA-binding transcription factor activity Source: BHF-UCL
Negative regulation of intracellular estrogen receptor signaling pathway Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry Source: BHF-UCL
Outflow tract morphogenesis Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Secondary heart field specification Source: Ensembl
Transforming growth factor beta receptor signaling pathway Source: BHF-UCL
Ventricular trabecula myocardium morphogenesis Source: Ensembl

Cellular Location

Nucleus