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Mouse Anti-FOXH1 Recombinant Antibody (CBXF-1777) (CBMAB-F3312-CQ)

This product is a mouse antibody that recognizes FOXH1. The antibody CBXF-1777 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all FOXH1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBXF-1777
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
forkhead box H1
Introduction
FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT.
Entrez Gene ID
Human8928
Mouse14106
Rat300054
UniProt ID
HumanO75593
MouseO88621
RatG3V7Y6
Alternative Names
Forkhead Box H1; Forkhead Activin Signal Transducer 2; HFAST-1; FAST-1; Fast-2; FAST1;
Function
Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).
Biological Process
Aorta morphogenesis Source: Ensembl
Axial mesoderm development Source: Ensembl
Cardiac right ventricle morphogenesis Source: Ensembl
Cellular response to cytokine stimulus Source: UniProtKB
Embryonic heart tube anterior/posterior pattern specification Source: Ensembl
Heart looping Source: Ensembl
Negative regulation of androgen receptor signaling pathway Source: BHF-UCL
Negative regulation of DNA-binding transcription factor activity Source: BHF-UCL
Negative regulation of intracellular estrogen receptor signaling pathway Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry Source: BHF-UCL
Outflow tract morphogenesis Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Secondary heart field specification Source: Ensembl
Transforming growth factor beta receptor signaling pathway Source: BHF-UCL
Ventricular trabecula myocardium morphogenesis Source: Ensembl
Cellular Location
Nucleus

Pluta, R., Aragón, E., Prescott, N. A., Ruiz, L., Mees, R. A., Baginski, B., ... & Macias, M. J. (2022). Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1. Nature Communications, 13(1), 7279.

Zhou, J. J., Pham, P. D., Han, H., Wang, W., & Cho, K. W. (2022). Engagement of Foxh1 in chromatin regulation revealed by protein interactome analyses. Development, Growth & Differentiation, 64(6), 297-305.

Ouyang, X., Feng, L., Yao, L., Zhang, J., Xiao, Y., Liu, G., ... & Wang, Z. (2022). A comprehensive analysis of FOX family in HCC and experimental evidence to support the oncogenic role of FOXH1. Aging (Albany NY), 14(5), 2268.

Zhang, J., Zhang, X., Yang, S., Bao, Y., Xu, D., & Liu, L. (2021). FOXH1 promotes lung cancer progression by activating the Wnt/β-catenin signaling pathway. Cancer cell international, 21(1), 1-13.

Afouda, B. A., Nakamura, Y., Shaw, S., Charney, R. M., Paraiso, K. D., Blitz, I. L., ... & Hoppler, S. (2020). Foxh1/Nodal defines context-specific direct maternal Wnt/β-catenin target gene regulation in early development. Iscience, 23(7), 101314.

Tao, W., Shi, H., Yang, J., Diakite, H., Kocher, T. D., & Wang, D. (2020). Homozygous mutation of foxh1 arrests oogenesis causing infertility in female Nile tilapia. Biology of Reproduction, 102(3), 758-769.

Aragón, E., Wang, Q., Zou, Y., Morgani, S. M., Ruiz, L., Kaczmarska, Z., ... & Massagué, J. (2019). Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling. Genes & development, 33(21-22), 1506-1524.

Wang, L., Su, Y., Huang, C., Yin, Y., Zhu, J., Knupp, A., ... & Tang, Y. (2019). FOXH1 Is Regulated by NANOG and LIN28 for Early-stage Reprogramming. Scientific Reports, 9(1), 16443.

Amelio, I. (2019). How mutant p53 empowers Foxh1 fostering leukaemogenesis?. Cell Death Discovery, 5(1), 108.

Fischer, P., Chen, H., Pacho, F., Rieder, D., Kimmel, R. A., & Meyer, D. (2019). FoxH1 represses miR-430 during early embryonic development of zebrafish via non-canonical regulation. BMC biology, 17, 1-17.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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