FRS2

FRS2 (Fibroblast Growth Factor Receptor Substrate 2) is a Protein Coding gene. Diseases associated with FRS2 include Retinitis Pigmentosa 32 and Inflammatory Mfh. Among its related pathways are RET signaling and Negative regulation of FGFR3 signaling. Gene Ontology (GO) annotations related to this gene include insulin receptor binding and transmembrane receptor protein tyrosine kinase adaptor activity. An important paralog of this gene is FRS3.

Full Name

Fibroblast Growth Factor Receptor Substrate 2

Function

Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.

Biological Process

Anterior/posterior axis specification, embryo Source: Ensembl
Fibroblast growth factor receptor signaling pathway Source: MGI
Forebrain development Source: Ensembl
Gastrulation with mouth forming second Source: Ensembl
G protein-coupled receptor signaling pathway Source: UniProtKB
Lens fiber cell development Source: Ensembl
Negative regulation of cardiac muscle cell differentiation Source: BHF-UCL
Neuroblast proliferation Source: Ensembl
Optic placode formation involved in camera-type eye formation Source: Ensembl
Organ induction Source: Ensembl
Positive regulation of MAPK cascade Source: Ensembl
Prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: Ensembl
Regulation of apoptotic process Source: Ensembl
Regulation of epithelial cell proliferation Source: Ensembl
Regulation of ERK1 and ERK2 cascade Source: Ensembl
Transmembrane receptor protein tyrosine phosphatase signaling pathway Source: UniProtKB
Ventricular septum development Source: Ensembl

Cellular Location

Endomembrane system. Cytoplasmic, membrane-bound.

PTM

Phosphorylated by ULK2 in vitro (By similarity). Phosphorylated on tyrosine residues upon stimulation by NGF or FGF2. Phosphorylated on tyrosine residues by activated ALK and FGFR1. Phosphorylated on tyrosine residues upon activation of FGFR2 and FGFR3. Phosphorylated on threonine residues by MAP kinases; this inhibits tyrosine phosphorylation, and thereby down-regulates FRS2-mediated activation of MAP kinases.
Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination (By similarity).