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Mouse Anti-FRS2 Recombinant Antibody (CBXF-2340) (CBMAB-F1410-CQ)

This product is a mouse antibody that recognizes FRS2. The antibody CBXF-2340 can be used for immunoassay techniques such as: ELISA, WB, IHC, IF.
See all FRS2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-2340
Antibody Isotype
IgG3
Application
ELISA, WB, IHC, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG3
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fibroblast Growth Factor Receptor Substrate 2
Introduction
FRS2 (Fibroblast Growth Factor Receptor Substrate 2) is a Protein Coding gene. Diseases associated with FRS2 include Retinitis Pigmentosa 32 and Inflammatory Mfh. Among its related pathways are RET signaling and Negative regulation of FGFR3 signaling. Gene Ontology (GO) annotations related to this gene include insulin receptor binding and transmembrane receptor protein tyrosine kinase adaptor activity. An important paralog of this gene is FRS3.
Entrez Gene ID
10818
UniProt ID
Q8WU20
Alternative Names
Fibroblast Growth Factor Receptor Substrate 2; Suc1-Associated Neurotrophic Factor Target 1; FGFR-Signaling Adaptor SNT; FGFR Substrate 2; SNT-1; FGFR Signalling Adaptor;
Function
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
Biological Process
Anterior/posterior axis specification, embryo Source: Ensembl
Fibroblast growth factor receptor signaling pathway Source: MGI
Forebrain development Source: Ensembl
Gastrulation with mouth forming second Source: Ensembl
G protein-coupled receptor signaling pathway Source: UniProtKB
Lens fiber cell development Source: Ensembl
Negative regulation of cardiac muscle cell differentiation Source: BHF-UCL
Neuroblast proliferation Source: Ensembl
Optic placode formation involved in camera-type eye formation Source: Ensembl
Organ induction Source: Ensembl
Positive regulation of MAPK cascade Source: Ensembl
Prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: Ensembl
Regulation of apoptotic process Source: Ensembl
Regulation of epithelial cell proliferation Source: Ensembl
Regulation of ERK1 and ERK2 cascade Source: Ensembl
Transmembrane receptor protein tyrosine phosphatase signaling pathway Source: UniProtKB
Ventricular septum development Source: Ensembl
Cellular Location
Endomembrane system. Cytoplasmic, membrane-bound.
PTM
Phosphorylated by ULK2 in vitro (By similarity). Phosphorylated on tyrosine residues upon stimulation by NGF or FGF2. Phosphorylated on tyrosine residues by activated ALK and FGFR1. Phosphorylated on tyrosine residues upon activation of FGFR2 and FGFR3. Phosphorylated on threonine residues by MAP kinases; this inhibits tyrosine phosphorylation, and thereby down-regulates FRS2-mediated activation of MAP kinases.
Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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