Mouse Anti-FRS2 Recombinant Antibody (CBXF-2340) (V2LY-1225-LY109)

Name: Mouse Anti-FRS2 Recombinant Antibody (CBXF-2340)
SKU: V2LY-1225-LY109
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-FRS2 Recombinant Antibody (CBXF-2340) (V2LY-1225-LY109) in Immunoblot

Immunoblot analysis was used to assess blockade of the FGF signalling pathway in A2780DPP cells in response to a AZD4547 (0-10 µM) and b SU5402 (0-10 µM). ...View More

Nicholson, H. A., Sawers, L., Clarke, R. G., Hiom, K. J., Ferguson, M. J., & Smith, G. (2022). Fibroblast growth factor signalling influences homologous recombination-mediated DNA damage repair to promote drug resistance in ovarian cancer. British journal of cancer, 127(7), 1340-1351.

Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXF-2340

Application

Immunogen

E. coli-derived recombinant human FRS2 (Asn121-Asn449).

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

Application	Note
WB	1 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, trehalose

Preservative

None

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Fibroblast Growth Factor Receptor Substrate 2

Entrez Gene ID

Human	10818
Mouse	327826

UniProt ID

Human	Q8WU20
Mouse	Q8C180

Function

Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.

Biological Process

Anterior/posterior axis specification, embryo Source: Ensembl
Fibroblast growth factor receptor signaling pathway Source: MGI
Forebrain development Source: Ensembl
Gastrulation with mouth forming second Source: Ensembl
G protein-coupled receptor signaling pathway Source: UniProtKB
Lens fiber cell development Source: Ensembl
Negative regulation of cardiac muscle cell differentiation Source: BHF-UCL
Neuroblast proliferation Source: Ensembl
Optic placode formation involved in camera-type eye formation Source: Ensembl
Organ induction Source: Ensembl
Positive regulation of MAPK cascade Source: Ensembl
Prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: Ensembl
Regulation of apoptotic process Source: Ensembl
Regulation of epithelial cell proliferation Source: Ensembl
Regulation of ERK1 and ERK2 cascade Source: Ensembl
Transmembrane receptor protein tyrosine phosphatase signaling pathway Source: UniProtKB
Ventricular septum development Source: Ensembl

Cellular Location

Endomembrane system. Cytoplasmic, membrane-bound.

PTM

Phosphorylated by ULK2 in vitro (By similarity). Phosphorylated on tyrosine residues upon stimulation by NGF or FGF2. Phosphorylated on tyrosine residues by activated ALK and FGFR1. Phosphorylated on tyrosine residues upon activation of FGFR2 and FGFR3. Phosphorylated on threonine residues by MAP kinases; this inhibits tyrosine phosphorylation, and thereby down-regulates FRS2-mediated activation of MAP kinases.
Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination (By similarity).

Wu, Q., Chen, J., Tan, Z., Wang, D., Zhou, J., Li, D., & Cen, Y. (2021). Long non-coding RNA (lncRNA) nuclear enriched abundant transcript 1 (NEAT1) regulates fibroblast growth factor receptor substrate 2 (FRS2) by targeting microRNA (miR)-29-3p in hypertrophic scar fibroblasts. Bioengineered, 12(1), 5210-5219.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-FRS2 Recombinant Antibody (CBXF-2340) (CAT#: CBMAB-F1410-CQ)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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