FZR1

FZR1 (Fizzy And Cell Division Cycle 20 Related 1) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Innate Immune System. An important paralog of this gene is CDC20.
Full Name
Fizzy And Cell Division Cycle 20 Related 1
Function
Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:25349192).
Biological Process
Anaphase-promoting complex-dependent catabolic process Source: UniProtKB
Cell division Source: UniProtKB-KW
DNA repair Source: UniProtKB-KW
Lens fiber cell differentiation Source: Ensembl
Mitotic G2 DNA damage checkpoint signaling Source: UniProtKB
Negative regulation of cell aging Source: Ensembl
Positive regulation of anaphase-promoting complex-dependent catabolic process Source: GO_Central
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of protein catabolic process Source: UniProtKB
Positive regulation of ubiquitin protein ligase activity Source: UniProtKB
Protein K11-linked ubiquitination Source: UniProtKB
Regulation of meiotic nuclear division Source: Ensembl
Cellular Location
Isoform 2: Nucleus
Isoform 3: Cytoplasm
PTM
Acetylated. Deacetylated by SIRT2 at Lys-69 and Lys-159; deacetylation enhances the interaction of FZR1 with CDC27, leading to activation of anaphase promoting complex/cyclosome (APC/C).
Phosphorylated during mitosis, probably by maturation promoting factor (MPF), leading to its dissociation of the APC/C. Following DNA damage, it is dephosphorylated by CDC14B in G2 phase, leading to its reassociation with the APC/C, and allowing an efficient G2 DNA damage checkpoint. Phosphorylated by MAK.
Ubiquitinated by the SCF(CCNF) E3 ubiquitin-protein ligase complex; leading to its degradation by the proteasome.
View more

Anti-FZR1 antibodies

+ Filters
Loading...

Mouse Anti-FZR1 Recombinant Antibody (3E12) (CBMAB-A3256-LY)

Go to compareCompare
Target: FZR1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3E12
Application*: WB, E
Datasheet SDS

Mouse Anti-FZR1 Recombinant Antibody (15A9.1) (CBMAB-C3229-LY)

Go to compareCompare
Target: FZR1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: 15A9.1
Application*: WB
Datasheet SDS

Mouse Anti-FZR1 Recombinant Antibody (CBXF-3273) (CBMAB-F3967-CQ)

Go to compareCompare
Target: FZR1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-3273
Application*: E, WB
Datasheet SDS

Mouse Anti-FZR1 Recombinant Antibody (CBXF-0998) (CBMAB-F3227-CQ)

Go to compareCompare
Target: FZR1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-0998
Application*: E, P, WB
Datasheet SDS

Mouse Anti-FZR1 Recombinant Antibody (DCS-266) (CBMAB-F2930-CQ)

Go to compareCompare
Target: FZR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: DCS-266
Application*: IP, WB
Datasheet SDS

Mouse Anti-FZR1 Recombinant Antibody (DH01 DCS-266) (CBMAB-F2778-CQ)

Go to compareCompare
Target: FZR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: DH01 DCS-266
Application*: WB, IF, IP
Datasheet SDS

Mouse Anti-FZR1 Recombinant Antibody (CBXF-3471) (CBMAB-F2059-CQ)

Go to compareCompare
Target: FZR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-3471
Application*: E, WB
Datasheet SDS

Mouse Anti-FZR1 Recombinant Antibody (CBXF-0997) (CBMAB-F1307-CQ)

Go to compareCompare
Target: FZR1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-0997
Application*: E, WB, P
Datasheet SDS

Mouse Anti-FZR1 Recombinant Antibody (4C4) (CBMAB-F1015-CQ)

Go to compareCompare
Target: FZR1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4C4
Application*: WB, P, SE
Datasheet SDS

Mouse Anti-FZR1 Recombinant Antibody (CBXF-0999) (CBMAB-F1014-CQ)

Go to compareCompare
Target: FZR1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-0999
Application*: WB, E, IF
Datasheet SDS

Mouse Anti-FZR1 Recombinant Antibody (AR38.2) (CBMAB-F0087-CQ)

Go to compareCompare
Target: FZR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: AR38.2
Application*: WB, E
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products

For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
online inquiry
Online Inquiry