FZR1
FZR1 (Fizzy And Cell Division Cycle 20 Related 1) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Innate Immune System. An important paralog of this gene is CDC20.
Full Name
Fizzy And Cell Division Cycle 20 Related 1
Function
Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:25349192).
Biological Process
Anaphase-promoting complex-dependent catabolic process Source: UniProtKB
Cell division Source: UniProtKB-KW
DNA repair Source: UniProtKB-KW
Lens fiber cell differentiation Source: Ensembl
Mitotic G2 DNA damage checkpoint signaling Source: UniProtKB
Negative regulation of cell aging Source: Ensembl
Positive regulation of anaphase-promoting complex-dependent catabolic process Source: GO_Central
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of protein catabolic process Source: UniProtKB
Positive regulation of ubiquitin protein ligase activity Source: UniProtKB
Protein K11-linked ubiquitination Source: UniProtKB
Regulation of meiotic nuclear division Source: Ensembl
Cell division Source: UniProtKB-KW
DNA repair Source: UniProtKB-KW
Lens fiber cell differentiation Source: Ensembl
Mitotic G2 DNA damage checkpoint signaling Source: UniProtKB
Negative regulation of cell aging Source: Ensembl
Positive regulation of anaphase-promoting complex-dependent catabolic process Source: GO_Central
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of protein catabolic process Source: UniProtKB
Positive regulation of ubiquitin protein ligase activity Source: UniProtKB
Protein K11-linked ubiquitination Source: UniProtKB
Regulation of meiotic nuclear division Source: Ensembl
Cellular Location
Isoform 2: Nucleus
Isoform 3: Cytoplasm
Isoform 3: Cytoplasm
PTM
Acetylated. Deacetylated by SIRT2 at Lys-69 and Lys-159; deacetylation enhances the interaction of FZR1 with CDC27, leading to activation of anaphase promoting complex/cyclosome (APC/C).
Phosphorylated during mitosis, probably by maturation promoting factor (MPF), leading to its dissociation of the APC/C. Following DNA damage, it is dephosphorylated by CDC14B in G2 phase, leading to its reassociation with the APC/C, and allowing an efficient G2 DNA damage checkpoint. Phosphorylated by MAK.
Ubiquitinated by the SCF(CCNF) E3 ubiquitin-protein ligase complex; leading to its degradation by the proteasome.
Phosphorylated during mitosis, probably by maturation promoting factor (MPF), leading to its dissociation of the APC/C. Following DNA damage, it is dephosphorylated by CDC14B in G2 phase, leading to its reassociation with the APC/C, and allowing an efficient G2 DNA damage checkpoint. Phosphorylated by MAK.
Ubiquitinated by the SCF(CCNF) E3 ubiquitin-protein ligase complex; leading to its degradation by the proteasome.
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Anti-FZR1 antibodies
+ Filters
Target: FZR1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3E12
Application*: WB, E
Target: FZR1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: 15A9.1
Application*: WB
Target: FZR1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-0997
Application*: WB, E, IH, PLA
Target: FZR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBXF-3273
Application*: WB, IP, IF, E, P
Target: FZR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Dog, Cattle, Pig
Clone: CBXF-0998
Application*: WB, IP, IF, E
Target: FZR1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-3471
Application*: WB, E
Target: FZR1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-3273
Application*: E, WB
Target: FZR1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-0998
Application*: E, P, WB
Target: FZR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 266
Application*: WB, IP, IF, P
Target: FZR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: DH01 DCS-266
Application*: WB, IF, IP
Target: FZR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-3471
Application*: E, WB
Target: FZR1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-0997
Application*: E, WB, P
Target: FZR1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4C4
Application*: WB, P, SE
Target: FZR1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-0999
Application*: WB, E, IF
Target: FZR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: AR38.2
Application*: WB, E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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