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Mouse Anti-FZR1 Recombinant Antibody (AR38.2) (CBMAB-F0087-CQ)

This product is a mouse antibody that recognizes FZR1. The antibody AR38.2 can be used for immunoassay techniques such as: WB, ELISA.
See all FZR1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
AR38.2
Antibody Isotype
IgG1
Application
WB, ELISA

Basic Information

Immunogen
Recombinant Fizzy Related Protein
Specificity
Human, Mouse
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fizzy And Cell Division Cycle 20 Related 1
Introduction
FZR1 (Fizzy And Cell Division Cycle 20 Related 1) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Innate Immune System. An important paralog of this gene is CDC20.
Entrez Gene ID
Human51343
Mouse56371
UniProt ID
HumanQ9UM11
MouseQ9R1K5
Alternative Names
Fizzy And Cell Division Cycle 20 Related 1; Fizzy/Cell Division Cycle 20 Related 1; CDC20-Like Protein 1; Cdh1/Hct1 Homolog; CDC20 Homolog 1; HCDH1; CDH1; FZR; Fizzy/Cell Division Cycle 20 Related 1 (Drosophila);
Function
Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:25349192).
Biological Process
Anaphase-promoting complex-dependent catabolic process Source: UniProtKB
Cell division Source: UniProtKB-KW
DNA repair Source: UniProtKB-KW
Lens fiber cell differentiation Source: Ensembl
Mitotic G2 DNA damage checkpoint signaling Source: UniProtKB
Negative regulation of cell aging Source: Ensembl
Positive regulation of anaphase-promoting complex-dependent catabolic process Source: GO_Central
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of protein catabolic process Source: UniProtKB
Positive regulation of ubiquitin protein ligase activity Source: UniProtKB
Protein K11-linked ubiquitination Source: UniProtKB
Regulation of meiotic nuclear division Source: Ensembl
Cellular Location
Isoform 2: Nucleus
Isoform 3: Cytoplasm
PTM
Acetylated. Deacetylated by SIRT2 at Lys-69 and Lys-159; deacetylation enhances the interaction of FZR1 with CDC27, leading to activation of anaphase promoting complex/cyclosome (APC/C).
Phosphorylated during mitosis, probably by maturation promoting factor (MPF), leading to its dissociation of the APC/C. Following DNA damage, it is dephosphorylated by CDC14B in G2 phase, leading to its reassociation with the APC/C, and allowing an efficient G2 DNA damage checkpoint. Phosphorylated by MAK.
Ubiquitinated by the SCF(CCNF) E3 ubiquitin-protein ligase complex; leading to its degradation by the proteasome.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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