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G3BP2

G3BP2 (GTPase activating protein binding protein 2) is an enzyme that in humans is encoded by the G3BP2 gene. G3BP2 has activities of nucleic acid binding and nucleotide binding. An important paralog of this gene is G3BP1.

Full Name

G3BP2

Function

Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling.

Biological Process

Cytoplasmic sequestering of NF-kappaB Source: UniProtKB
Innate immune response Source: UniProtKB-KW
mRNA transport Source: UniProtKB-KW
Positive regulation of stress granule assembly Source: UniProtKB
Protein homooligomerization Source: UniProtKB
Ras protein signal transduction Source: UniProtKB
Stress granule assembly Source: InterPro

Cellular Location

Cytoplasm; Stress granule

PTM

Arg-457 and Arg-468 are dimethylated, probably to asymmetric dimethylarginine.
(Microbial infection) Cleaved by foot-and-mouth disease virus leader protease; this cleavage suppresses the formation of cytoplasmic stress granules.

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Anti-G3BP2 antibodies

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Mouse Anti-G3BP2 Recombinant Antibody (EG1262) (V2LY-1225-LY463)

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Target: G3BP2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: EG1262

Application*: WB, IF

Rabbit Anti-G3BP2 Recombinant Antibody (EG1262) (CBMAB-EN1525-LY)

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Target: G3BP2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EG1262

Application*: WB: 1:500~1:1000 ELISA: 1:10000

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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