G3BP2

G3BP2 (GTPase activating protein binding protein 2) is an enzyme that in humans is encoded by the G3BP2 gene. G3BP2 has activities of nucleic acid binding and nucleotide binding. An important paralog of this gene is G3BP1.

Full Name

G3BP2

Function

Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling.

Biological Process

Cytoplasmic sequestering of NF-kappaB Source: UniProtKB
Innate immune response Source: UniProtKB-KW
mRNA transport Source: UniProtKB-KW
Positive regulation of stress granule assembly Source: UniProtKB
Protein homooligomerization Source: UniProtKB
Ras protein signal transduction Source: UniProtKB
Stress granule assembly Source: InterPro

Cellular Location

Cytoplasm; Stress granule

PTM

Arg-457 and Arg-468 are dimethylated, probably to asymmetric dimethylarginine.
(Microbial infection) Cleaved by foot-and-mouth disease virus leader protease; this cleavage suppresses the formation of cytoplasmic stress granules.

Anti-G3BP2 antibodies

Rabbit Anti-G3BP2 Recombinant Antibody (EG1262) (CBMAB-EN1525-LY)

Datasheet

SDS

Target: G3BP2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EG1262

Application*: WB: 1:500~1:1000 ELISA: 1:10000

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)