GAB1

The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Full Name
GRB2 Associated Binding Protein 1
Function
Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807).
Biological Process
Actin cytoskeleton reorganization Source: BHF-UCL
Angiogenesis Source: BHF-UCL
Endothelial cell chemotaxis to vascular endothelial growth factor Source: BHF-UCL
Epidermal growth factor receptor signaling pathway Source: ProtInc
Insulin receptor signaling pathway Source: ProtInc
Positive regulation of angiogenesis Source: BHF-UCL
Positive regulation of cell migration by vascular endothelial growth factor signaling pathway Source: BHF-UCL
Response to hepatocyte growth factor Source: Ensembl
Vascular endothelial growth factor signaling pathway Source: BHF-UCL
Cellular Location
Cytosol; Cell-cell junction
Involvement in disease
Deafness, autosomal recessive, 26 (DFNB26):
A form of non-syndromic sensorineural deafness characterized by prelingual, severe to profound hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
PTM
Phosphorylated in response to FGFR1 activation. Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. Phosphorylated on tyrosine residues by HCK upon IL6 signaling.
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Anti-GAB1 antibodies

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Rabbit Anti-GAB1 (Phosphorylated Y627) Recombinant Antibody (C32H2) (PTM-CBMAB-0110LY)

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Target: GAB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: C32H2
Application*: WB
Datasheet SDS

Rat Anti-GAB1 Recombinant Antibody (W15218A) (CBMAB-G1585-LY)

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Target: GAB1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: W15218A
Application*: WB
Datasheet SDS

Mouse Anti-GAB1 Recombinant Antibody (5F11C8) (CBMAB-G1584-LY)

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Target: GAB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5F11C8
Application*: E, WB
Datasheet SDS

Mouse Anti-GAB1 Recombinant Antibody (1B3) (CBMAB-G1583-LY)

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Target: GAB1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1B3
Application*: E, WB
Datasheet SDS

Mouse Anti-GAB1 Recombinant Antibody (1A7) (CBMAB-G1581-LY)

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Target: GAB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A7
Application*: WB
Datasheet SDS

Rabbit Anti-GAB1 Recombinant Antibody (Y423) (CBMAB-G0110-LY)

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Target: GAB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: Y423
Application*: IC/IF
Datasheet SDS

Rabbit Anti-GAB1 Recombinant Antibody (CBLG1-2500) (CBMAB-G0109-LY)

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Target: GAB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2500
Application*: F
Datasheet SDS

Mouse Anti-GAB1 Recombinant Antibody (CBT2120) (V2LY-0625-LY2770)

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Target: GAB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2120
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-GAB1 Recombinant Antibody (CBT3258) (V2LY-0625-LY257)

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Target: GAB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3258
Application*: F
Datasheet SDS

GAB1 Matched Antibody Pair (459) (APMAB-459LY)

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Target: GAB1
Specificity: Human
Datasheet SDS

GAB1 Matched Antibody Pair (458) (APMAB-458LY)

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Target: GAB1
Specificity: Human
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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