GAB1

The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

GRB2 Associated Binding Protein 1

Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807).

Actin cytoskeleton reorganization Source: BHF-UCL
Angiogenesis Source: BHF-UCL
Endothelial cell chemotaxis to vascular endothelial growth factor Source: BHF-UCL
Epidermal growth factor receptor signaling pathway Source: ProtInc
Insulin receptor signaling pathway Source: ProtInc
Positive regulation of angiogenesis Source: BHF-UCL
Positive regulation of cell migration by vascular endothelial growth factor signaling pathway Source: BHF-UCL
Response to hepatocyte growth factor Source: Ensembl
Vascular endothelial growth factor signaling pathway Source: BHF-UCL

Cytosol; Cell-cell junction

Deafness, autosomal recessive, 26 (DFNB26):
A form of non-syndromic sensorineural deafness characterized by prelingual, severe to profound hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

Phosphorylated in response to FGFR1 activation. Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. Phosphorylated on tyrosine residues by HCK upon IL6 signaling.