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Rabbit Anti-GAB1 Recombinant Antibody (Y423) (CBMAB-G0110-LY)

This product is antibody recognizes GAB1. The antibody Y423 immunoassay techniques such as: ICC/IF.
See all GAB1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
Y423
Antibody Isotype
IgG
Application
ICC/IF

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
GRB2 Associated Binding Protein 1
Introduction
The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Entrez Gene ID
2549
UniProt ID
Q13480
Alternative Names
GRB2 Associated Binding Protein 1; Growth Factor Receptor Bound Protein 2-Associated Protein 1; GRB2-Associated Binder 1;
Function
Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807).
Biological Process
Actin cytoskeleton reorganization Source: BHF-UCL
Angiogenesis Source: BHF-UCL
Endothelial cell chemotaxis to vascular endothelial growth factor Source: BHF-UCL
Epidermal growth factor receptor signaling pathway Source: ProtInc
Insulin receptor signaling pathway Source: ProtInc
Positive regulation of angiogenesis Source: BHF-UCL
Positive regulation of cell migration by vascular endothelial growth factor signaling pathway Source: BHF-UCL
Response to hepatocyte growth factor Source: Ensembl
Vascular endothelial growth factor signaling pathway Source: BHF-UCL
Cellular Location
Cytosol; Cell-cell junction
Involvement in disease
Deafness, autosomal recessive, 26 (DFNB26):
A form of non-syndromic sensorineural deafness characterized by prelingual, severe to profound hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
PTM
Phosphorylated in response to FGFR1 activation. Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. Phosphorylated on tyrosine residues by HCK upon IL6 signaling.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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