Rabbit Anti-GAB1 Recombinant Antibody (Y423) (CBMAB-G0110-LY)

Name: Rabbit Anti-GAB1 Recombinant Antibody (Y423)
SKU: CBMAB-G0110-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

Y423

Application

ICC/IF

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

50% glycerol

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

GRB2 Associated Binding Protein 1

Introduction

The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Entrez Gene ID

2549

UniProt ID

Q13480

Alternative Names

GRB2 Associated Binding Protein 1; Growth Factor Receptor Bound Protein 2-Associated Protein 1; GRB2-Associated Binder 1;

Function

Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807).

Biological Process

Actin cytoskeleton reorganization Source: BHF-UCL
Angiogenesis Source: BHF-UCL
Endothelial cell chemotaxis to vascular endothelial growth factor Source: BHF-UCL
Epidermal growth factor receptor signaling pathway Source: ProtInc
Insulin receptor signaling pathway Source: ProtInc
Positive regulation of angiogenesis Source: BHF-UCL
Positive regulation of cell migration by vascular endothelial growth factor signaling pathway Source: BHF-UCL
Response to hepatocyte growth factor Source: Ensembl
Vascular endothelial growth factor signaling pathway Source: BHF-UCL

Cellular Location

Cytosol; Cell-cell junction

Involvement in disease

Deafness, autosomal recessive, 26 (DFNB26):
A form of non-syndromic sensorineural deafness characterized by prelingual, severe to profound hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

PTM

Phosphorylated in response to FGFR1 activation. Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. Phosphorylated on tyrosine residues by HCK upon IL6 signaling.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

GAB1 Matched Antibody Pair (458) (CAT#: APMAB-458LY)

GAB1 Matched Antibody Pair (459) (CAT#: APMAB-459LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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