Mouse Anti-GAB1 Recombinant Antibody (23) (V2LY-1225-LY475)

Name: Mouse Anti-GAB1 Recombinant Antibody (23)
SKU: V2LY-1225-LY475
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 665-690 at the C-terminus of human Gab1.

Host Species

Mouse

Specificity

Human, Mouse, Rat, Dog, Cattle

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

Application	Note
ELISA	1:100-1:1,000
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, gelatin

Preservative

Sodium azide

Concentration

0.2 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

GRB2 Associated Binding Protein 1

Entrez Gene ID

Human	2549
Mouse	14388
Rat	361388

UniProt ID

Human	Q13480
Mouse	Q9QYY0
Rat	D3ZAL7

Function

Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807).

Biological Process

Actin cytoskeleton reorganization Source: BHF-UCL
Angiogenesis Source: BHF-UCL
Endothelial cell chemotaxis to vascular endothelial growth factor Source: BHF-UCL
Epidermal growth factor receptor signaling pathway Source: ProtInc
Insulin receptor signaling pathway Source: ProtInc
Positive regulation of angiogenesis Source: BHF-UCL
Positive regulation of cell migration by vascular endothelial growth factor signaling pathway Source: BHF-UCL
Response to hepatocyte growth factor Source: Ensembl
Vascular endothelial growth factor signaling pathway Source: BHF-UCL

Cellular Location

Cytosol; Cell-cell junction

Involvement in disease

Deafness, autosomal recessive, 26 (DFNB26):
A form of non-syndromic sensorineural deafness characterized by prelingual, severe to profound hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

PTM

Phosphorylated in response to FGFR1 activation. Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. Phosphorylated on tyrosine residues by HCK upon IL6 signaling.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

GAB1 Matched Antibody Pair (458) (CAT#: APMAB-458LY)

GAB1 Matched Antibody Pair (459) (CAT#: APMAB-459LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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