GAB2

This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
Full Name
GRB2 Associated Binding Protein 2
Function
Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.
Biological Process
Osteoclast differentiation Source: UniProtKB
Phosphatidylinositol-mediated signaling Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of mast cell degranulation Source: UniProtKB
Cellular Location
Cytoplasm; Cell membrane
PTM
Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R (By similarity). Phosphorylated upon stimulation of TNFRSF11A/RANK by TNFSF11/RANKL (By similarity). Phosphorylated upon EGF stimulation. Phosphorylated on tyrosine residues by HCK upon IL6 signaling.
Dephosphorylated by PTPN11.
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Anti-GAB2 antibodies

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Rabbit Anti-GAB2 Recombinant Antibody (26B6) (CBMAB-G1586-LY)

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Target: GAB2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: 26B6
Application*: WB
Datasheet SDS

Rabbit Anti-GAB2 Recombinant Antibody (CBLG1-2501) (CBMAB-G0111-LY)

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Target: GAB2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2501
Application*: F
Datasheet SDS

Mouse Anti-GAB2 Recombinant Antibody (69) (CBMAB-1300-YC)

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Target: GAB2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 69
Application*: IF, IH, F, E
Datasheet SDS

Rabbit Anti-GAB2 Recombinant Antibody (33G1) (V2LY-1225-LY484)

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Target: GAB2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 33G1
Application*: WB, IP
Datasheet SDS

Mouse Anti-GAB2 Recombinant Antibody (26B6) (V2LY-1225-LY483)

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Target: GAB2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 26B6
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-GAB2 (Phospho-Tyr452) Recombinant Antibody (CBLG1-2501) (V2LY-1225-LY482)

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Target: GAB2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBLG1-2501
Application*: WB
Datasheet SDS

Mouse Anti-GAB2 Recombinant Antibody (CBT3941) (V2LY-0625-LY167)

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Target: GAB2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT3941
Application*: IH, IC, F
Datasheet SDS

Rabbit Anti-GAB2 (Phosphorylated Y452) Recombinant Antibody (C33G1) (PTM-CBMAB-0111LY)

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Target: GAB2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: C33G1
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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