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Rabbit Anti-GAB2 Monoclonal Antibody (EP369Y) (CBMAB-1300-YC)

Provided herein is a rabbit monoclonal antibody against Human GAB2. The antibody, clone EP369Y, can be used for immunoassay techniques, such as ICC, IF, FC and WB.
See all GAB2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EP369Y
Antibody Isotype
IgG
Application
ICC, IF, FC, WB

Basic Information

Immunogen
Synthetic peptide corresponding to residues in human Gab2
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
GRB2 Associated Binding Protein 2
Introduction
GRB2-associated binding protein act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. GAB2 is a member of the GRB2-associated binding protein (GAB) gene family. GAB2 is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor.
Entrez Gene ID
Human9846
Mouse14389
Rat84477
UniProt ID
HumanQ9UQC2
MouseQ9Z1S8
RatQ9EQH1
Alternative Names
Grb2-associated binder 2; growth factor receptor bound protein 2-associated protein 2; pp100
Function
Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.
Biological Process
Osteoclast differentiation Source: UniProtKB
Phosphatidylinositol-mediated signaling Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of mast cell degranulation Source: UniProtKB
Cellular Location
Cytoplasm; Cell membrane
PTM
Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R (By similarity). Phosphorylated upon stimulation of TNFRSF11A/RANK by TNFSF11/RANKL (By similarity). Phosphorylated upon EGF stimulation. Phosphorylated on tyrosine residues by HCK upon IL6 signaling.
Dephosphorylated by PTPN11.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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