Mouse Anti-GAB2 Recombinant Antibody (69) (CBMAB-1300-YC)

Name: Mouse Anti-GAB2 Recombinant Antibody (69)
SKU: CBMAB-1300-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

Application

IF, IHC, FC, ELISA

Immunogen

Human GAB2.

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
ELISA	1:10,000
IF(ICC)	1:200-1:1,000
IHC	1:200-1:1,000
FC	1:200-1:400

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

1 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

GRB2 Associated Binding Protein 2

Introduction

GRB2-associated binding protein act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. GAB2 is a member of the GRB2-associated binding protein (GAB) gene family. GAB2 is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor.

Entrez Gene ID

9846

UniProt ID

Q9UQC2

Alternative Names

Grb2-associated binder 2; growth factor receptor bound protein 2-associated protein 2; pp100

Function

Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.

Biological Process

Osteoclast differentiation Source: UniProtKB
Phosphatidylinositol-mediated signaling Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of mast cell degranulation Source: UniProtKB

Cellular Location

Cytoplasm; Cell membrane

PTM

Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R (By similarity). Phosphorylated upon stimulation of TNFRSF11A/RANK by TNFSF11/RANKL (By similarity). Phosphorylated upon EGF stimulation. Phosphorylated on tyrosine residues by HCK upon IL6 signaling.
Dephosphorylated by PTPN11.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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