Rabbit Anti-GAB2 Monoclonal Antibody (EP369Y) (CBMAB-1300-YC)

Name: Rabbit Anti-GAB2 Monoclonal Antibody (EP369Y)
SKU: CBMAB-1300-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

EP369Y

Application

ICC, IF, FC, WB

Immunogen

Synthetic peptide corresponding to residues in human Gab2

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

GRB2 Associated Binding Protein 2

Introduction

GRB2-associated binding protein act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. GAB2 is a member of the GRB2-associated binding protein (GAB) gene family. GAB2 is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor.

Entrez Gene ID

Human	9846
Mouse	14389
Rat	84477

UniProt ID

Human	Q9UQC2
Mouse	Q9Z1S8
Rat	Q9EQH1

Alternative Names

Grb2-associated binder 2; growth factor receptor bound protein 2-associated protein 2; pp100

Function

Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.

Biological Process

Osteoclast differentiation Source: UniProtKB
Phosphatidylinositol-mediated signaling Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of mast cell degranulation Source: UniProtKB

Cellular Location

Cytoplasm; Cell membrane

PTM

Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R (By similarity). Phosphorylated upon stimulation of TNFRSF11A/RANK by TNFSF11/RANKL (By similarity). Phosphorylated upon EGF stimulation. Phosphorylated on tyrosine residues by HCK upon IL6 signaling.
Dephosphorylated by PTPN11.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Rabbit Anti-GAB2 Recombinant Antibody (CBLG1-2501) (CAT#: CBMAB-G0111-LY)

Rabbit Anti-GAB2 Recombinant Antibody (26B6) (CAT#: CBMAB-G1586-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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