Rabbit Anti-GAB2 (Phospho-Tyr452) Recombinant Antibody (CBLG1-2501) (V2LY-1225-LY482)

Name: Rabbit Anti-GAB2 (Phospho-Tyr452) Recombinant Antibody (CBLG1-2501)
SKU: V2LY-1225-LY482
Rating: 5 (1 reviews)

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Published Data

Rabbit Anti-GAB2 (Phospho-Tyr452) Recombinant Antibody (CBLG1-2501) (V2LY-1225-LY482) in WB

Western blot analysis of phospho-Syk, phospho-Gab2, phospho-p65, phospho-p38, phospho-MK2, and phospho-Akt in BMMCs stimulated with antigen for up to 20 min in the presence or absence of 25 μM resveratrol. The level of β-actin is shown at the bottom as a loading control. ...View More

Nakajima, S., Ishimaru, K., Kobayashi, A., Yu, G., Nakamura, Y., Oh-Oka, K., Suzuki-Inoue, K., Kono, K., & Nakao, A. (2019). Resveratrol inhibits IL-33-mediated mast cell activation by targeting the MK2/3-PI3K/Akt axis. Scientific reports, 9(1), 18423.

Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

CBLG1-2501

Application

Immunogen

Synthetic phosphopeptide corresponding to residues surrounding Tyr452 of human Gab2.

Host Species

Rabbit

Specificity

Human, Mouse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

Application	Note
WB	1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

HEPES, BSA, glycerol

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

GRB2 Associated Binding Protein 2

Entrez Gene ID

Human	9846
Mouse	14389

UniProt ID

Human	Q9UQC2
Mouse	Q9Z1S8

Function

Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.

Biological Process

Osteoclast differentiation Source: UniProtKB
Phosphatidylinositol-mediated signaling Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of mast cell degranulation Source: UniProtKB

Cellular Location

Cytoplasm; Cell membrane

PTM

Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R (By similarity). Phosphorylated upon stimulation of TNFRSF11A/RANK by TNFSF11/RANKL (By similarity). Phosphorylated upon EGF stimulation. Phosphorylated on tyrosine residues by HCK upon IL6 signaling.
Dephosphorylated by PTPN11.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rabbit Anti-GAB2 Recombinant Antibody (CBLG1-2501) (CAT#: CBMAB-G0111-LY)

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Rabbit Anti-GAB2 (Phosphorylated Y452) Recombinant Antibody (C33G1) (CAT#: PTM-CBMAB-0111LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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