GADD45A
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]
Full Name
Growth Arrest And DNA Damage Inducible Alpha
Function
In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity).
Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.
Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.
Biological Process
Activation of MAPKKK activity Source: UniProtKB
Apoptotic process Source: ProtInc
Cellular response to ionizing radiation Source: BHF-UCL
Cellular response to mechanical stimulus Source: UniProtKB
Centrosome cycle Source: Ensembl
DNA repair Source: ProtInc
Negative regulation of angiogenesis Source: Ensembl
Negative regulation of blood vessel endothelial cell migration Source: CACAO
Negative regulation of peptidyl-serine phosphorylation of STAT protein Source: CACAO
Negative regulation of protein serine/threonine kinase activity Source: CACAO
Negative regulation of transcription by RNA polymerase II Source: CACAO
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of JNK cascade Source: UniProtKB
Positive regulation of p38MAPK cascade Source: UniProtKB
Positive regulation of reactive oxygen species metabolic process Source: BHF-UCL
Regulation of cell cycle Source: GO_Central
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Signal transduction in response to DNA damage Source: BHF-UCL
Apoptotic process Source: ProtInc
Cellular response to ionizing radiation Source: BHF-UCL
Cellular response to mechanical stimulus Source: UniProtKB
Centrosome cycle Source: Ensembl
DNA repair Source: ProtInc
Negative regulation of angiogenesis Source: Ensembl
Negative regulation of blood vessel endothelial cell migration Source: CACAO
Negative regulation of peptidyl-serine phosphorylation of STAT protein Source: CACAO
Negative regulation of protein serine/threonine kinase activity Source: CACAO
Negative regulation of transcription by RNA polymerase II Source: CACAO
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of JNK cascade Source: UniProtKB
Positive regulation of p38MAPK cascade Source: UniProtKB
Positive regulation of reactive oxygen species metabolic process Source: BHF-UCL
Regulation of cell cycle Source: GO_Central
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Signal transduction in response to DNA damage Source: BHF-UCL
Cellular Location
Nucleus
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Anti-GADD45A antibodies
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CompareTarget: GADD45A
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-165
Tag: GST Tag
Target: GADD45A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3D12
Application*: WB, E, PLA
Target: GADD45A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBLG1-492
Application*: WB, IP, E
Target: GADD45A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBLG1-491
Application*: WB, IP, IF, E, F
Target: GADD45A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-2526
Application*: WB, IP, IF, E
Target: GADD45A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: G1770
Application*: WB
Target: GADD45A
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBLG1-3136
Application*: WB, IP, IF, E
Target: GADD45A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-492
Application*: WB
Target: GADD45A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-491
Application*: WB
Target: GADD45A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLG1-2526
Application*: WB
Target: GADD45A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D17E8
Application*: WB
Target: GADD45A
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBLG1-3136
Application*: WB
Target: GADD45A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3D12
Application*: E, WB
Target: GADD45A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2B7
Application*: WB
Target: GADD45A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1C9
Application*: WB
Target: GADD45A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey, Mouse, Rat
Clone: 10E22D17E8
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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