GADD45A

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]
Full Name
Growth Arrest And DNA Damage Inducible Alpha
Function
In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity).

Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.
Biological Process
Activation of MAPKKK activity Source: UniProtKB
Apoptotic process Source: ProtInc
Cellular response to ionizing radiation Source: BHF-UCL
Cellular response to mechanical stimulus Source: UniProtKB
Centrosome cycle Source: Ensembl
DNA repair Source: ProtInc
Negative regulation of angiogenesis Source: Ensembl
Negative regulation of blood vessel endothelial cell migration Source: CACAO
Negative regulation of peptidyl-serine phosphorylation of STAT protein Source: CACAO
Negative regulation of protein serine/threonine kinase activity Source: CACAO
Negative regulation of transcription by RNA polymerase II Source: CACAO
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of JNK cascade Source: UniProtKB
Positive regulation of p38MAPK cascade Source: UniProtKB
Positive regulation of reactive oxygen species metabolic process Source: BHF-UCL
Regulation of cell cycle Source: GO_Central
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Signal transduction in response to DNA damage Source: BHF-UCL
Cellular Location
Nucleus
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Anti-GADD45A antibodies

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Mouse Anti-GADD45A Recombinant Antibody (CBLG1-492) (CBMAB-G1775-LY)

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Target: GADD45A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-492
Application*: WB
Datasheet SDS

Rabbit Anti-GADD45A Recombinant Antibody (CBLG1-491) (CBMAB-G1774-LY)

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Target: GADD45A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-491
Application*: WB
Datasheet SDS

Mouse Anti-GADD45A Recombinant Antibody (CBLG1-2526) (CBMAB-G1771-LY)

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Target: GADD45A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLG1-2526
Application*: WB
Datasheet SDS

Rabbit Anti-GADD45A Recombinant Antibody (D17E8) (CBMAB-G1770-LY)

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Target: GADD45A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D17E8
Application*: WB
Datasheet SDS

Mouse Anti-GADD45A Recombinant Antibody (CBLG1-3136) (CBMAB-G1768-LY)

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Target: GADD45A
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBLG1-3136
Application*: WB
Datasheet SDS

Mouse Anti-GADD45A Recombinant Antibody (3D12) (CBMAB-G1766-LY)

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Target: GADD45A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3D12
Application*: E, WB
Datasheet SDS

Mouse Anti-GADD45A Recombinant Antibody (2B7) (CBMAB-G1765-LY)

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Target: GADD45A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2B7
Application*: WB
Datasheet SDS

Mouse Anti-GADD45A Recombinant Antibody (1C9) (CBMAB-G1764-LY)

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Target: GADD45A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1C9
Application*: WB
Datasheet SDS

Rabbit Anti-GADD45A Recombinant Antibody (10E22D17E8) (CBMAB-G1763-LY)

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Target: GADD45A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey, Mouse, Rat
Clone: 10E22D17E8
Application*: WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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