GADD45A

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]

Growth Arrest And DNA Damage Inducible Alpha

In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity).

Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.

Activation of MAPKKK activity Source: UniProtKB
Apoptotic process Source: ProtInc
Cellular response to ionizing radiation Source: BHF-UCL
Cellular response to mechanical stimulus Source: UniProtKB
Centrosome cycle Source: Ensembl
DNA repair Source: ProtInc
Negative regulation of angiogenesis Source: Ensembl
Negative regulation of blood vessel endothelial cell migration Source: CACAO
Negative regulation of peptidyl-serine phosphorylation of STAT protein Source: CACAO
Negative regulation of protein serine/threonine kinase activity Source: CACAO
Negative regulation of transcription by RNA polymerase II Source: CACAO
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of JNK cascade Source: UniProtKB
Positive regulation of p38MAPK cascade Source: UniProtKB
Positive regulation of reactive oxygen species metabolic process Source: BHF-UCL
Regulation of cell cycle Source: GO_Central
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Signal transduction in response to DNA damage Source: BHF-UCL

Nucleus