Rabbit Anti-GADD45A Recombinant Antibody (G1770) (V2LY-1225-LY590)

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Basic Information

Host Animal
Rabbit
Clone
G1770
Application
WB
Immunogen
Synthetic peptide corresponding to amino acids surrounding Asn129 of human GADD45α.
Host Species
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
ApplicationNote
WB1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
HEPES, BSA, glycerol
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Growth Arrest And DNA Damage Inducible Alpha
Entrez Gene ID
Human1647
Mouse13197
Rat25112
Monkey701054
UniProt ID
HumanP24522
MouseP48316
RatP48317
MonkeyA0A2K5VD54
Function
In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity).

Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.
Biological Process
Activation of MAPKKK activity Source: UniProtKB
Apoptotic process Source: ProtInc
Cellular response to ionizing radiation Source: BHF-UCL
Cellular response to mechanical stimulus Source: UniProtKB
Centrosome cycle Source: Ensembl
DNA repair Source: ProtInc
Negative regulation of angiogenesis Source: Ensembl
Negative regulation of blood vessel endothelial cell migration Source: CACAO
Negative regulation of peptidyl-serine phosphorylation of STAT protein Source: CACAO
Negative regulation of protein serine/threonine kinase activity Source: CACAO
Negative regulation of transcription by RNA polymerase II Source: CACAO
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of JNK cascade Source: UniProtKB
Positive regulation of p38MAPK cascade Source: UniProtKB
Positive regulation of reactive oxygen species metabolic process Source: BHF-UCL
Regulation of cell cycle Source: GO_Central
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Signal transduction in response to DNA damage Source: BHF-UCL
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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