Sign in or Register   Sign in or Register
  |  

Mouse Anti-GADD45A Recombinant Antibody (CBLG1-3136) (CBMAB-G1768-LY)

This product is antibody recognizes GADD45A. The antibody CBLG1-3136 immunoassay techniques such as: WB.
See all GADD45A antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBLG1-3136
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Growth Arrest And DNA Damage Inducible Alpha
Introduction
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]
Entrez Gene ID
Human1647
Mouse13197
Rat25112
UniProt ID
HumanP24522
MouseP48316
RatP48317
Function
In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity).

Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.
Biological Process
Activation of MAPKKK activity Source: UniProtKB
Apoptotic process Source: ProtInc
Cellular response to ionizing radiation Source: BHF-UCL
Cellular response to mechanical stimulus Source: UniProtKB
Centrosome cycle Source: Ensembl
DNA repair Source: ProtInc
Negative regulation of angiogenesis Source: Ensembl
Negative regulation of blood vessel endothelial cell migration Source: CACAO
Negative regulation of peptidyl-serine phosphorylation of STAT protein Source: CACAO
Negative regulation of protein serine/threonine kinase activity Source: CACAO
Negative regulation of transcription by RNA polymerase II Source: CACAO
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of JNK cascade Source: UniProtKB
Positive regulation of p38MAPK cascade Source: UniProtKB
Positive regulation of reactive oxygen species metabolic process Source: BHF-UCL
Regulation of cell cycle Source: GO_Central
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Signal transduction in response to DNA damage Source: BHF-UCL
Cellular Location
Nucleus
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-GADD45A Recombinant Antibody (CBLG1-3136)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare