GPLD1

Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane.

Full Name

Glycosylphosphatidylinositol Specific Phospholipase D1

Function

This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane.

Biological Process

Cell migration involved in sprouting angiogenesis Source: UniProtKB
Cellular response to calcium ion Source: UniProtKB
Cellular response to cholesterol Source: UniProtKB
Cellular response to drug Source: UniProtKB
Cellular response to insulin stimulus Source: UniProtKB
Cellular response to pH Source: UniProtKB
Cellular response to triglyceride Source: UniProtKB
Chondrocyte differentiation Source: UniProtKB
Complement receptor mediated signaling pathway Source: UniProtKB
C-terminal protein lipidation Source: Reactome
GPI anchor release Source: UniProtKB
Hematopoietic stem cell migration Source: UniProtKB
Hematopoietic stem cell migration to bone marrow Source: UniProtKB
Insulin receptor signaling pathway Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of triglyceride catabolic process Source: UniProtKB
Ossification Source: UniProtKB
Phosphatidylcholine metabolic process Source: UniProtKB
Positive regulation of alkaline phosphatase activity Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of endothelial cell migration Source: UniProtKB
Positive regulation of glucose metabolic process Source: UniProtKB
Positive regulation of high-density lipoprotein particle clearance Source: UniProtKB
Positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: UniProtKB
Positive regulation of membrane protein ectodomain proteolysis Source: UniProtKB
Positive regulation of secretion Source: UniProtKB
Positive regulation of triglyceride biosynthetic process Source: UniProtKB
Regulation of cellular response to insulin stimulus Source: UniProtKB
Response to glucose Source: UniProtKB
Transepithelial transport Source: UniProtKB

Cellular Location

Secreted