Mouse Anti-GPLD1 Recombinant Antibody (38A1) (CBMAB-G4600-LY)

Glycosylphosphatidylinositol Specific Phospholipase D1

Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. [provided by RefSeq, Jul 2008]

Glycosylphosphatidylinositol Specific Phospholipase D1; Glycoprotein Phospholipase D; GPI-Specific Phospholipase D; EC 3.1.4.50; PI-G PLD; GPI-PLD; PIGPLD1;

This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane.

Cell migration involved in sprouting angiogenesis Source: UniProtKB
Cellular response to calcium ion Source: UniProtKB
Cellular response to cholesterol Source: UniProtKB
Cellular response to drug Source: UniProtKB
Cellular response to insulin stimulus Source: UniProtKB
Cellular response to pH Source: UniProtKB
Cellular response to triglyceride Source: UniProtKB
Chondrocyte differentiation Source: UniProtKB
Complement receptor mediated signaling pathway Source: UniProtKB
C-terminal protein lipidation Source: Reactome
GPI anchor release Source: UniProtKB
Hematopoietic stem cell migration Source: UniProtKB
Hematopoietic stem cell migration to bone marrow Source: UniProtKB
Insulin receptor signaling pathway Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of triglyceride catabolic process Source: UniProtKB
Ossification Source: UniProtKB
Phosphatidylcholine metabolic process Source: UniProtKB
Positive regulation of alkaline phosphatase activity Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of endothelial cell migration Source: UniProtKB
Positive regulation of glucose metabolic process Source: UniProtKB
Positive regulation of high-density lipoprotein particle clearance Source: UniProtKB
Positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: UniProtKB
Positive regulation of membrane protein ectodomain proteolysis Source: UniProtKB
Positive regulation of secretion Source: UniProtKB
Positive regulation of triglyceride biosynthetic process Source: UniProtKB
Regulation of cellular response to insulin stimulus Source: UniProtKB
Response to glucose Source: UniProtKB
Transepithelial transport Source: UniProtKB

Secreted