GRK3

The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.
Full Name
G protein-coupled receptor kinase 3
Function
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.
Biological Process
Desensitization of G protein-coupled receptor signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: GO_Central
Protein phosphorylation Source: GO_Central
Receptor internalization Source: UniProtKB
Regulation of signal transduction Source: GO_Central
Signal transduction Source: ProtInc
Cellular Location
Cytosol; Plasma membrane
PTM
Ubiquitinated.
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Anti-GRK3 antibodies

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Rabbit Anti-GRK3 Recombinant Antibody (CBLG1-1783) (CBMAB-G4995-LY)

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Target: GRK3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBLG1-1783
Application*: WB
Datasheet SDS

Mouse Anti-GRK3 Recombinant Antibody (497018) (CBMAB-G0803-LY)

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Target: GRK3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 497018
Application*: WB
Datasheet SDS

Rabbit Anti-GRK3 Recombinant Antibody (EG1445) (CBMAB-EN1726-LY)

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Target: GRK3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG1445
Application*: WB: 1:500~1:1000 ELISA: 1:20000
Datasheet SDS
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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