GRK5

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs).
Full Name
G protein-coupled receptor kinase 5
Biological Process
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: ProtInc
Apoptotic process Source: UniProtKB-KW
G protein-coupled receptor signaling pathway Source: Reactome
Negative regulation of apoptotic process Source: UniProtKB
Positive regulation of cell population proliferation Source: CACAO
Protein autophosphorylation Source: UniProtKB
Protein phosphorylation Source: GO_Central
Regulation of cell cycle Source: CACAO
Regulation of G protein-coupled receptor signaling pathway Source: ProtInc
Regulation of signal transduction Source: GO_Central
Tachykinin receptor signaling pathway Source: BHF-UCL
Wnt signaling pathway Source: UniProtKB-KW
Cellular Location
Cell membrane; Nucleus; Cytoplasm. Predominantly localized at the plasma membrane; targeted to the cell surface through the interaction with phospholipids. Nucleus localization is regulated in a GPCR and Ca2+/calmodulin-dependent fashion.
PTM
Autophosphorylated. Autophosphorylation may play a critical role in the regulation of GRK5 kinase activity.
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Anti-GRK5 antibodies

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Mouse Anti-GRK5 Monoclonal Antibody (16) (CBMAB-G5012-LY)

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Target: GRK5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Pig, Rabbit
Clone: 16
Application*: E
Datasheet SDS

Mouse Anti-GRK5 Monoclonal Antibody (20) (CBMAB-G0806-LY)

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Target: GRK5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 20
Application*: WB, IF
Datasheet SDS

Mouse Anti-GRK5 Recombinant Antibody (CBFYH-0489) (CBMAB-H1358-FY)

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Target: GRK5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-0489
Application*: IF
Datasheet SDS

Mouse Anti-GRK5 Recombinant Antibody (CBFYH-0488) (CBMAB-H0276-FY)

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Target: GRK5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBFYH-0488
Application*: E, IP, IF, WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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