HDGF

This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many tumors. This gene was thought initially to be located on chromosome X; however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2016]
Full Name
Heparin Binding Growth Factor
Function
Isoform 1:
Acts as a transcriptional repressor (PubMed:17974029).

Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719).

Heparin-binding protein (PubMed:15491618).

Isoform 2:
Does not have mitogenic activity for fibroblasts (PubMed:26845719).

Does not bind heparin (PubMed:26845719).

Isoform 3:
Has mitogenic activity for fibroblasts (PubMed:26845719).

Heparin-binding protein (PubMed:26845719).
Biological Process
Cellular response to interleukin-7 Source: Ensembl
Negative regulation of neuron apoptotic process Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of cell division Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Protein localization to nucleus Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Signal transduction Source: ProtInc
Cellular Location
Isoform 1: Nucleus; Extracellular exosome; Cytoplasm. Secreted by exosomes and is located inside the exosome (PubMed:27926477). May also be secreted as free protein via an as yet unknown pathway (PubMed:27926477).
Isoform 2: Nucleus; Extracellular exosome; Cytoplasm. Secreted by exosomes and is located on the outer exosome surface.
Isoform 3: Nucleus; Extracellular exosome; Cytoplasm. Secreted by exosomes and is located on the outer exosome surface.
PTM
Sumoylated with SUMO1. Sumoylation prevents binding to chromatin.
Phosphorylation at Ser-165 is likely to be required for secretion.
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Anti-HDGF antibodies

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Mouse Anti-HDGF Recombinant Antibody (2D6) (CBMAB-A3809-LY)

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Target: HDGF
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2D6
Application*: WB, E
Datasheet SDS

Mouse Anti-HDGF Antibody (1D1) (CBMAB-0448-YC)

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Target: HDGF
Host: Mouse
Antibody Isotype: IgG2c
Specificity: Human
Clone: 1D1
Application*: IP, WB, M
Datasheet SDS

Mouse Anti-HDGF Recombinant Antibody (1230) (CBMAB-AP2691LY)

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Target: HDGF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 1230
Application*: ELISA, IF, IHC, WB
Datasheet SDS

Mouse Anti-HDGF Recombinant Antibody (CF199) (CBMAB-FT291LY)

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Target: HDGF
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CF199
Application*: ELISA, WB, IHC, IF
Datasheet SDS

Rat Anti-HDGF Recombinant Antibody (CBFYH-3545) (CBMAB-H4097-FY)

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Target: HDGF
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBFYH-3545
Application*: WB
Datasheet SDS

Mouse Anti-HDGF Recombinant Antibody (CBFYH-0904) (CBMAB-H1835-FY)

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Target: HDGF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0904
Application*: WB
Datasheet SDS

Mouse Anti-HDGF Recombinant Antibody (CBFYH-0903) (CBMAB-H1834-FY)

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Target: HDGF
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-0903
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-HDGF Recombinant Antibody (CBFYH-0902) (CBMAB-H1833-FY)

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Target: HDGF
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBFYH-0902
Application*: E, WB, IH, IF
Datasheet SDS

Mouse Anti-HDGF Monoclonal Antibody (CBFYH-3046) (CBMAB-H1831-FY)

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Target: HDGF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-3046
Application*: WB, P, DB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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