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Mouse Anti-HDGF Antibody (1D1) (CBMAB-0448-YC)

Provided herein are mouse monoclonal antibodies against Human HDGF. The antibody clone 1D1 can be used for immunoassay techniques, such as IP, WB and MA.
See all HDGF antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1D1
Antibody Isotype
IgG2c
Application
IP, WB, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2c
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Heparin Binding Growth Factor
Introduction
HDGF (hepatoma-derived growth factor) is a member of the hepatoma-derived growth factor family, which has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of HDGF gene enhance the growth of many tumors.
Entrez Gene ID
3068
UniProt ID
P51858
Alternative Names
HMG1L2
Function
Isoform 1:
Acts as a transcriptional repressor (PubMed:17974029).

Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719).

Heparin-binding protein (PubMed:15491618).

Isoform 2:
Does not have mitogenic activity for fibroblasts (PubMed:26845719).

Does not bind heparin (PubMed:26845719).

Isoform 3:
Has mitogenic activity for fibroblasts (PubMed:26845719).

Heparin-binding protein (PubMed:26845719).
Biological Process
Cellular response to interleukin-7 Source: Ensembl
Negative regulation of neuron apoptotic process Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of cell division Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Protein localization to nucleus Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Signal transduction Source: ProtInc
Cellular Location
Isoform 1: Nucleus; Extracellular exosome; Cytoplasm. Secreted by exosomes and is located inside the exosome (PubMed:27926477). May also be secreted as free protein via an as yet unknown pathway (PubMed:27926477).
Isoform 2: Nucleus; Extracellular exosome; Cytoplasm. Secreted by exosomes and is located on the outer exosome surface.
Isoform 3: Nucleus; Extracellular exosome; Cytoplasm. Secreted by exosomes and is located on the outer exosome surface.
PTM
Sumoylated with SUMO1. Sumoylation prevents binding to chromatin.
Phosphorylation at Ser-165 is likely to be required for secretion.

Fang, Y., & Yang, Q. (2022). Specificity protein 1-induced serine peptidase inhibitor, Kunitz type 1 antisense RNA1 regulates colorectal cancer cell proliferation, migration, invasion and apoptosis through targeting heparin binding growth factor via sponging microRNA-214. Bioengineered, 13(2), 3309-3322.

Qiu, L., Ma, Y., Chen, X., Zhou, L., Zhang, H., Zhong, G., ... & Tang, J. (2021). Heparin-binding growth factor (HDGF) drives radioresistance in breast cancer by activating the STAT3 signaling pathway. Journal of Translational Medicine, 19(1), 344.

Xia, C., Li, Q., Cheng, X., Wu, T., & Gao, P. (2021). miR-4323 targets hepatoma-derived growth factor (HDGF) to suppress colorectal cancer cell proliferation. Pathology-Research and Practice, 225, 153544.

Keppie, S. J., Mansfield, J. C., Tang, X., Philp, C. J., Graham, H. K., Önnerfjord, P., ... & Vincent, T. L. (2021). Matrix-bound growth factors are released upon cartilage compression by an aggrecan-dependent sodium flux that is lost in osteoarthritis. Function, 2(5), zqab037.

Keppie, S. J. (2021). Bioavailability of matrix-bound growth factors in cartilage injury (Doctoral dissertation, University of Oxford).

Eguchi, R., & Wakabayashi, I. (2020). HDGF enhances VEGF‑dependent angiogenesis and FGF‑2 is a VEGF‑independent angiogenic factor in non‑small cell lung cancer. Oncology reports, 44(1), 14-28.

Zhang, C., Chang, X., Chen, D., Yang, F., Li, Z., Li, D., ... & Xu, Z. (2019). Downregulation of HDGF inhibits the tumorigenesis of bladder cancer cells by inactivating the PI3K-AKT signaling pathway. Cancer Management and Research, 7909-7923.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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