HVCN1

This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Full Name

Hydrogen Voltage Gated Channel 1

Function

Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis.

Biological Process

Cell redox homeostasis Source: Reactome
Cellular response to pH Source: UniProtKB
Cellular response to zinc ion Source: UniProtKB
Positive regulation of superoxide anion generation Source: Ensembl
Proton transmembrane transport Source: UniProtKB
Regulation of intracellular pH Source: Ensembl
Regulation of ion transmembrane transport Source: UniProtKB-KW
Response to pH Source: HGNC-UCL
Response to zinc ion Source: HGNC-UCL

Cellular Location

Cell membrane; Membrane. Detected mainly at intracellular membranes upon overexpression in HeLa cells (PuMed:20147290), but not in other cell types.

Topology

Cytoplasmic: 1-100
Helical: 101-121
Extracellular: 122-138
Helical: 139-161
Cytoplasmic: 162-169
Helical: 170-190
Extracellular: 191-197
Helical: 198-218
Cytoplasmic: 219-273

PTM

Phosphorylation may enhance channel gating.