IFNAR2

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene.
Full Name
Interferon Alpha And Beta Receptor Subunit 2
Function
Associates with IFNAR1 to form the plasma membrane receptor in the type I interferon signaling pathway (PubMed:26424569, PubMed:28165510, PubMed:32972995).

Directly involved in signal transduction through its association with the TYR kinase JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950).

Involved in interferon-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569, PubMed:32972995).

Isoform 3:
Potent inhibitor of type I IFN receptor activity.
Biological Process
Cell surface receptor signaling pathway Source: ProtInc
Cytokine-mediated signaling pathway Source: GO_Central
Defense response to virus Source: UniProtKB
Receptor signaling pathway via JAK-STAT Source: ProtInc
Response to interferon-alpha Source: UniProtKB
Response to interferon-beta Source: UniProtKB
Response to virus Source: ProtInc
Type I interferon signaling pathway Source: UniProtKB
Cellular Location
Isoform 1&2: Cell membrane
Isoform 3: Secreted
Involvement in disease
Immunodeficiency 45 (IMD45):
An autosomal recessive disorder characterized by increased susceptibility to viral infection due to impaired antiviral immunity, resulting in infection-associated encephalopathy. Affected individuals are at risk for developing fatal encephalitis after routine measles/mumps/rubella (MMR) vaccination.
Topology
Extracellular: 27-243
Helical: 244-264
Cytoplasmic: 265-515
PTM
Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types.
Glycosylated.
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Anti-IFNAR2 antibodies

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Human IFNAR2 ELISA Kit (V2LY-0626-LY4741)

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Target: IFNAR2
Sensitivity: 0.026 ng/mL
Detection Range: 0.05-10 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Cynomolgus Recombinant Interferon alpha/beta receptor 2 protein, ECD, His Tag (V2LY-0526-LY1587)

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Target: IFNAR2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-243
Tag: His Tag
Datasheet SDS

Human Recombinant IFNAR2 protein, His Tag (V2LY-0526-LY5049)

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Target: IFNAR2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-243
Tag: His Tag
Datasheet SDS

Human Recombinant IFNAR2 protein, Biotin Conjugated, His Tag (V2LY-0526-LY5048)

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Target: IFNAR2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-243
Tag: His Tag
Datasheet SDS

Human Recombinant IFNAR2 protein, hFc Tag (V2LY-0526-LY5047)

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Target: IFNAR2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-243
Tag: hFc Tag
Datasheet SDS

Human Recombinant IFNAR2 protein, Biotin Conjugated, hFc Tag (V2LY-0526-LY5046)

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Target: IFNAR2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-243
Tag: hFc Tag
Datasheet SDS

Rat Anti-IFNAR2 Recombinant Antibody (CBYY-I1091) (CBMAB-I2259-YY)

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Target: IFNAR2
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-I1091
Application*: WB
Datasheet SDS

Mouse Anti-IFNAR2 Recombinant Antibody (CBYY-I0715) (CBMAB-I1594-YY)

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Target: IFNAR2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0715
Application*: E, WB
Datasheet SDS

Human Anti-IFNAR2 Recombinant Antibody (CBYY-I0407) (CBMAB-I1004-YY)

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Target: IFNAR2
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0407
Application*: F
Datasheet SDS

Mouse Anti-IFNAR2 Recombinant Antibody (MMHAR-2) (CBMAB-I0891-YY)

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Target: IFNAR2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: MMHAR-2
Application*: F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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