Human Anti-IFNAR2 Recombinant Antibody (CBYY-I0407) (CBMAB-I1004-YY)

Name: Human Anti-IFNAR2 Recombinant Antibody (CBYY-I0407)
SKU: CBMAB-I1004-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Human

Clone

CBYY-I0407

Application

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Preservative

0.05% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Interferon Alpha And Beta Receptor Subunit 2

Introduction

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene.

Entrez Gene ID

3455

UniProt ID

P48551

Alternative Names

Interferon Alpha And Beta Receptor Subunit 2

Function

Associates with IFNAR1 to form the plasma membrane receptor in the type I interferon signaling pathway (PubMed:26424569, PubMed:28165510, PubMed:32972995).

Directly involved in signal transduction through its association with the TYR kinase JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950).

Involved in interferon-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569, PubMed:32972995).

Isoform 3:
Potent inhibitor of type I IFN receptor activity.

Biological Process

Cell surface receptor signaling pathway Source: ProtInc
Cytokine-mediated signaling pathway Source: GO_Central
Defense response to virus Source: UniProtKB
Receptor signaling pathway via JAK-STAT Source: ProtInc
Response to interferon-alpha Source: UniProtKB
Response to interferon-beta Source: UniProtKB
Response to virus Source: ProtInc
Type I interferon signaling pathway Source: UniProtKB

Cellular Location

Isoform 1&2: Cell membrane
Isoform 3: Secreted

Involvement in disease

Immunodeficiency 45 (IMD45):
An autosomal recessive disorder characterized by increased susceptibility to viral infection due to impaired antiviral immunity, resulting in infection-associated encephalopathy. Affected individuals are at risk for developing fatal encephalitis after routine measles/mumps/rubella (MMR) vaccination.

Topology

Extracellular: 27-243
Helical: 244-264
Cytoplasmic: 265-515

PTM

Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types.
Glycosylated.

Duncan, C. J., Skouboe, M. K., Howarth, S., Hollensen, A. K., Chen, R., Børresen, M. L., ... & Mogensen, T. H. (2022). Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic. Journal of Experimental Medicine, 219(6), e20212427.

Dieter, C., de Almeida Brondani, L., Lemos, N. E., Schaeffer, A. F., Zanotto, C., Ramos, D. T., ... & Crispim, D. (2022). Polymorphisms in ACE1, TMPRSS2, IFIH1, IFNAR2, and TYK2 genes are associated with worse clinical outcomes in COVID-19. Genes, 14(1), 29.

Fricke-Galindo, I., Martínez-Morales, A., Chávez-Galán, L., Ocaña-Guzmán, R., Buendía-Roldán, I., Pérez-Rubio, G., ... & Falfán-Valencia, R. (2022). IFNAR2 relevance in the clinical outcome of individuals with severe COVID-19. Frontiers in Immunology, 13, 949413.

Meyts, I. (2022). Null IFNAR1 and IFNAR2 alleles are surprisingly common in the Pacific and Arctic.

Zhang, L., Ma, J., Jin, X., Zhang, L., Zhang, M., Li, P. Z., ... & Zhang, L. (2022). Human IFNAR2 Mutant Generated by CRISPR/Cas9-Induced Exon Skipping Upregulates a Subset of Tonic-Like Interferon-Stimulated Genes Upon IFNβ Stimulation. Journal of Interferon & Cytokine Research, 42(11), 580-589.

Akter, S., Roy, A. S., Tonmoy, M. I. Q., & Islam, M. S. (2022). Deleterious single nucleotide polymorphisms (SNPs) of human IFNAR2 gene facilitate COVID-19 severity in patients: a comprehensive in silico approach. Journal of Biomolecular Structure and Dynamics, 40(21), 11173-11189.

Shemesh, M., Lochte, S., Piehler, J., & Schreiber, G. (2021). IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon–induced JAK-STAT signaling and activating STATs. Science signaling, 14(710), eabe4627.

Smieszek, S. P., Polymeropoulos, V. M., Xiao, C., Polymeropoulos, C. M., & Polymeropoulos, M. H. (2021). Loss-of-function mutations in IFNAR2 in COVID-19 severe infection susceptibility. Journal of Global Antimicrobial Resistance, 26, 239-240.

Passarelli, C., Civino, A., Rossi, M. N., Cifaldi, L., Lanari, V., Moneta, G. M., ... & Prencipe, G. (2020). IFNAR2 deficiency causing dysregulation of NK cell functions and presenting with hemophagocytic lymphohistiocytosis. Frontiers in Genetics, 11, 937.

Shepardson, K. M., Larson, K., Johns, L. L., Stanek, K., Cho, H., Wellham, J., ... & Rynda-Apple, A. (2018). IFNAR2 is required for anti-influenza immunity and alters susceptibility to post-influenza bacterial superinfections. Frontiers in immunology, 9, 2589.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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