IFNB1

This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015]

Interferon Beta 1

Has antiviral, antibacterial and anticancer activities.

Adaptive immune response Source: GO_Central
B cell activation involved in immune response Source: UniProtKB
B cell differentiation Source: GO_Central
B cell proliferation Source: GO_Central
Cell surface receptor signaling pathway Source: ProtInc
Cellular response to exogenous dsRNA Source: BHF-UCL
Cellular response to interferon-beta Source: BHF-UCL
Cellular response to virus Source: ARUK-UCL
Cytokine-mediated signaling pathway Source: GO_Central
Defense response to virus Source: BHF-UCL
Humoral immune response Source: GO_Central
Natural killer cell activation Source: UniProtKB
Natural killer cell activation involved in immune response Source: GO_Central
Negative regulation of T cell differentiation Source: UniProtKB
Negative regulation of T-helper 2 cell cytokine production Source: UniProtKB
Negative regulation of viral genome replication Source: BHF-UCL
Positive regulation of apoptotic signaling pathway Source: UniProtKB
Positive regulation of innate immune response Source: UniProtKB
Positive regulation of peptidyl-serine phosphorylation of STAT protein Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of MHC class I biosynthetic process Source: UniProtKB
Response to exogenous dsRNA Source: MGI
Response to virus Source: UniProtKB
T cell activation involved in immune response Source: GO_Central
Type I interferon signaling pathway Source: BHF-UCL

Secreted