Mouse Anti-IFNB1 Recombinant Antibody (B-A15) (CBMAB-I1954-YY)

Name: Mouse Anti-IFNB1 Recombinant Antibody (B-A15)
SKU: CBMAB-I1954-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

B-A15

Application

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

1 % BSA

Preservative

0.1 % sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Interferon Beta 1

Introduction

This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection.

Entrez Gene ID

3458

UniProt ID

P01579

Alternative Names

Interferon Beta 1

Function

Has antiviral, antibacterial and anticancer activities.

Biological Process

Adaptive immune response Source: GO_Central
B cell activation involved in immune response Source: UniProtKB
B cell differentiation Source: GO_Central
B cell proliferation Source: GO_Central
Cell surface receptor signaling pathway Source: ProtInc
Cellular response to exogenous dsRNA Source: BHF-UCL
Cellular response to interferon-beta Source: BHF-UCL
Cellular response to virus Source: ARUK-UCL
Cytokine-mediated signaling pathway Source: GO_Central
Defense response to virus Source: BHF-UCL
Humoral immune response Source: GO_Central
Natural killer cell activation Source: UniProtKB
Natural killer cell activation involved in immune response Source: GO_Central
Negative regulation of T cell differentiation Source: UniProtKB
Negative regulation of T-helper 2 cell cytokine production Source: UniProtKB
Negative regulation of viral genome replication Source: BHF-UCL
Positive regulation of apoptotic signaling pathway Source: UniProtKB
Positive regulation of innate immune response Source: UniProtKB
Positive regulation of peptidyl-serine phosphorylation of STAT protein Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of MHC class I biosynthetic process Source: UniProtKB
Response to exogenous dsRNA Source: MGI
Response to virus Source: UniProtKB
T cell activation involved in immune response Source: GO_Central
Type I interferon signaling pathway Source: BHF-UCL

Cellular Location

Secreted

Schwanke, H., Gonçalves Magalhães, V., Schmelz, S., Wyler, E., Hennig, T., Günther, T., ... & Brinkmann, M. M. (2023). The Cytomegalovirus M35 Protein Directly Binds to the Interferon-β Enhancer and Modulates Transcription of Ifnb1 and Other IRF3-Driven Genes. Journal of Virology, e00400-23.

Zhang, Y., Huang, H., Chen, H., Zhang, P., Liu, Y., Gan, Y., ... & Ren, H. (2023). Unearths IFNB1 immune infiltrates in SOP-related ossification of ligamentum flavum pathogenesis. Heliyon.

Schwanke, H., Goncalves Magalhaes, V., Schmelz, S., Wyler, E., Hennig, T., Guenther, T., ... & Brinkmann, M. M. (2023). The Cytomegalovirus M35 Protein Modulates Transcription of Ifnb1 and Other IRF3-Driven Genes by Direct Promoter Binding. bioRxiv, 2023-03.

Thomsen, E. A., Andersen, S., Marqvorsen, M. H. S., Skipper, K. A., Paludan, S. R., & Mikkelsen, J. G. (2022). Single-Cell Monitoring of Activated Innate Immune Signaling by a d2eGFP-Based Reporter Mimicking Time-Restricted Activation of IFNB1 Expression. Frontiers in Cellular and Infection Microbiology, 11, 784762.

Schwanke, H., Stempel, M., & Brinkmann, M. M. (2020). Of keeping and tipping the balance: host regulation and viral modulation of IRF3-dependent IFNB1 expression. Viruses, 12(7), 733.

Cho, E., Islam, S. B. U., Jiang, F., Park, J. E., Lee, B., Kim, N. D., & Hwang, T. H. (2020). Characterization of oncolytic vaccinia virus harboring the human IFNB1 and CES2 transgenes. Cancer Research and Treatment: Official Journal of Korean Cancer Association, 52(1), 309-319.

Nikopoulou, C., Panagopoulos, G., Sianidis, G., Psarra, E., Ford, E., & Thanos, D. (2019). The Transcription Factor ThPOK Orchestrates Stochastic Interchromosomal Interactions Required for IFNB1 Virus-Inducible Gene Expression. Molecular Cell, 74(2), 409-410.

Nikopoulou, C., Panagopoulos, G., Sianidis, G., Psarra, E., Ford, E., & Thanos, D. (2018). The transcription factor ThPOK orchestrates stochastic interchromosomal interactions required for IFNB1 virus-inducible gene expression. Molecular cell, 71(2), 352-361.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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