Human Recombinant IFNB1 protein, hFc Tag (V2LY-0526-LY4652)

Name: Human Recombinant IFNB1 protein, hFc Tag
SKU: V2LY-0526-LY4652
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant IFNB1 protein, hFc Tag consist of Amino Acid: 1-187 and predicts a molecular mass of 46.7 kDa.

Molecule Mass

46.7 kDa

Sequence

Amino Acid: 1-187

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Interferon Beta 1

Alternative Names

Interferon Beta 1

Function

Has antiviral, antibacterial and anticancer activities.

Biological Process

Adaptive immune response Source: GO_Central
B cell activation involved in immune response Source: UniProtKB
B cell differentiation Source: GO_Central
B cell proliferation Source: GO_Central
Cell surface receptor signaling pathway Source: ProtInc
Cellular response to exogenous dsRNA Source: BHF-UCL
Cellular response to interferon-beta Source: BHF-UCL
Cellular response to virus Source: ARUK-UCL
Cytokine-mediated signaling pathway Source: GO_Central
Defense response to virus Source: BHF-UCL
Humoral immune response Source: GO_Central
Natural killer cell activation Source: UniProtKB
Natural killer cell activation involved in immune response Source: GO_Central
Negative regulation of T cell differentiation Source: UniProtKB
Negative regulation of T-helper 2 cell cytokine production Source: UniProtKB
Negative regulation of viral genome replication Source: BHF-UCL
Positive regulation of apoptotic signaling pathway Source: UniProtKB
Positive regulation of innate immune response Source: UniProtKB
Positive regulation of peptidyl-serine phosphorylation of STAT protein Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of MHC class I biosynthetic process Source: UniProtKB
Response to exogenous dsRNA Source: MGI
Response to virus Source: UniProtKB
T cell activation involved in immune response Source: GO_Central
Type I interferon signaling pathway Source: BHF-UCL

Cellular Location

Secreted

Schwanke, H., Gonçalves Magalhães, V., Schmelz, S., Wyler, E., Hennig, T., Günther, T., ... & Brinkmann, M. M. (2023). The Cytomegalovirus M35 Protein Directly Binds to the Interferon-β Enhancer and Modulates Transcription of Ifnb1 and Other IRF3-Driven Genes. Journal of Virology, e00400-23.

Zhang, Y., Huang, H., Chen, H., Zhang, P., Liu, Y., Gan, Y., ... & Ren, H. (2023). Unearths IFNB1 immune infiltrates in SOP-related ossification of ligamentum flavum pathogenesis. Heliyon.

Schwanke, H., Goncalves Magalhaes, V., Schmelz, S., Wyler, E., Hennig, T., Guenther, T., ... & Brinkmann, M. M. (2023). The Cytomegalovirus M35 Protein Modulates Transcription of Ifnb1 and Other IRF3-Driven Genes by Direct Promoter Binding. bioRxiv, 2023-03.

Thomsen, E. A., Andersen, S., Marqvorsen, M. H. S., Skipper, K. A., Paludan, S. R., & Mikkelsen, J. G. (2022). Single-Cell Monitoring of Activated Innate Immune Signaling by a d2eGFP-Based Reporter Mimicking Time-Restricted Activation of IFNB1 Expression. Frontiers in Cellular and Infection Microbiology, 11, 784762.

Schwanke, H., Stempel, M., & Brinkmann, M. M. (2020). Of keeping and tipping the balance: host regulation and viral modulation of IRF3-dependent IFNB1 expression. Viruses, 12(7), 733.

Cho, E., Islam, S. B. U., Jiang, F., Park, J. E., Lee, B., Kim, N. D., & Hwang, T. H. (2020). Characterization of oncolytic vaccinia virus harboring the human IFNB1 and CES2 transgenes. Cancer Research and Treatment: Official Journal of Korean Cancer Association, 52(1), 309-319.

Nikopoulou, C., Panagopoulos, G., Sianidis, G., Psarra, E., Ford, E., & Thanos, D. (2019). The Transcription Factor ThPOK Orchestrates Stochastic Interchromosomal Interactions Required for IFNB1 Virus-Inducible Gene Expression. Molecular Cell, 74(2), 409-410.

Nikopoulou, C., Panagopoulos, G., Sianidis, G., Psarra, E., Ford, E., & Thanos, D. (2018). The transcription factor ThPOK orchestrates stochastic interchromosomal interactions required for IFNB1 virus-inducible gene expression. Molecular cell, 71(2), 352-361.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant IFNB1 protein (CAT#: V2LY-0526-LY4651)

Mouse Recombinant IFNB1 protein (CAT#: V2LY-0526-LY8432)

Mouse Recombinant IFNB1 protein, hFc Tag (CAT#: V2LY-0526-LY8433)

Rhesus Recombinant IFNB1 protein, Fc Tag (CAT#: V2LY-0526-LY9729)

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Rhesus Recombinant IFNB1 protein, Fc Tag (CAT#: V2LY-0526-LY9729)

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Human Recombinant IFNB1 protein (CAT#: V2LY-0526-LY4651)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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