IGFBP5

IGFBP5 (Insulin Like Growth Factor Binding Protein 5) is a Protein Coding gene. Diseases associated with IGFBP5 include Insulin-Like Growth Factor I and Renal Osteodystrophy. Among its related pathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include fibronectin binding and insulin-like growth factor I binding. An important paralog of this gene is IGFBP3.

Full Name

Insulin Like Growth Factor Binding Protein 5

Function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Biological Process

Aging Source: Ensembl
Cellular response to cAMP Source: UniProtKB
Cellular response to organic cyclic compound Source: UniProtKB
Female pregnancy Source: Ensembl
Glucose homeostasis Source: Ensembl
Hair follicle morphogenesis Source: Ensembl
Intracellular signal transduction Source: Ensembl
Lung alveolus development Source: Ensembl
Mammary gland involution Source: Ensembl
Negative regulation of cell migration Source: BHF-UCL
Negative regulation of growth Source: Ensembl
Negative regulation of insulin-like growth factor receptor signaling pathway Source: BHF-UCL
Negative regulation of muscle tissue development Source: Ensembl
Negative regulation of osteoblast differentiation Source: Ensembl
Negative regulation of skeletal muscle hypertrophy Source: Ensembl
Negative regulation of smooth muscle cell migration Source: BHF-UCL
Negative regulation of smooth muscle cell proliferation Source: BHF-UCL
Negative regulation of translation Source: BHF-UCL
Osteoblast differentiation Source: Ensembl
Positive regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
Positive regulation of protein kinase B signaling Source: Ensembl
Positive regulation of vascular associated smooth muscle cell migration Source: BHF-UCL
Positive regulation of vascular associated smooth muscle cell proliferation Source: BHF-UCL
Regulation of cell growth Source: Ensembl
Regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
Response to growth hormone Source: AgBase
Signal transduction Source: ProtInc
Striated muscle cell differentiation Source: Ensembl
Type B pancreatic cell proliferation Source: Ensembl

Cellular Location

Secreted