Human IGFBP5 ELISA Kit (2) (V2LY-0626-LY5886)

Name: Human IGFBP5 ELISA Kit (2)
SKU: V2LY-0626-LY5886
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.023 ng/mL

Detection Range

0.05-20 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

30.6 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Insulin Like Growth Factor Binding Protein 5

Function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Biological Process

Aging Source: Ensembl
Cellular response to cAMP Source: UniProtKB
Cellular response to organic cyclic compound Source: UniProtKB
Female pregnancy Source: Ensembl
Glucose homeostasis Source: Ensembl
Hair follicle morphogenesis Source: Ensembl
Intracellular signal transduction Source: Ensembl
Lung alveolus development Source: Ensembl
Mammary gland involution Source: Ensembl
Negative regulation of cell migration Source: BHF-UCL
Negative regulation of growth Source: Ensembl
Negative regulation of insulin-like growth factor receptor signaling pathway Source: BHF-UCL
Negative regulation of muscle tissue development Source: Ensembl
Negative regulation of osteoblast differentiation Source: Ensembl
Negative regulation of skeletal muscle hypertrophy Source: Ensembl
Negative regulation of smooth muscle cell migration Source: BHF-UCL
Negative regulation of smooth muscle cell proliferation Source: BHF-UCL
Negative regulation of translation Source: BHF-UCL
Osteoblast differentiation Source: Ensembl
Positive regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
Positive regulation of protein kinase B signaling Source: Ensembl
Positive regulation of vascular associated smooth muscle cell migration Source: BHF-UCL
Positive regulation of vascular associated smooth muscle cell proliferation Source: BHF-UCL
Regulation of cell growth Source: Ensembl
Regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
Response to growth hormone Source: AgBase
Signal transduction Source: ProtInc
Striated muscle cell differentiation Source: Ensembl
Type B pancreatic cell proliferation Source: Ensembl

Cellular Location

Secreted

Uzuncakmak, S. K., Aksakal, A., Kerget, F., Aydın, P., & Halıcı, Z. (2023). Evaluation of IGFBP5 expression and plasma osteopontin level in COVID-19 patients. Advances in Medical Sciences, 68(1), 31-37.

Dittmer, J. (2022). Biological effects and regulation of IGFBP5 in breast cancer. Frontiers in Endocrinology, 13, 983793.

Song, C., Wang, S., Fu, Z., Chi, K., Geng, X., Liu, C., ... & Hong, Q. (2022). IGFBP5 promotes diabetic kidney disease progression by enhancing PFKFB3-mediated endothelial glycolysis. Cell Death & Disease, 13(4), 340.

Hao, J., Yang, H., Cao, Y., Zhang, C., & Fan, Z. (2020). IGFBP5 enhances the dentinogenesis potential of dental pulp stem cells via JNK and ErK signalling pathways. Journal of Oral Rehabilitation, 47(12), 1557-1565.

Ji, Y., Zhang, W., Yang, J., & Li, C. (2020). MiR-193b inhibits autophagy and apoptosis by targeting IGFBP5 in high glucose-induced trophoblasts. Placenta, 101, 185-193.

Dong, C., Zhang, J., Fang, S., & Liu, F. (2020). IGFBP5 increases cell invasion and inhibits cell proliferation by EMT and Akt signaling pathway in Glioblastoma multiforme cells. Cell division, 15(1), 1-9.

Xiao, Z., Chu, Y., & Qin, W. (2020). IGFBP5 modulates lipid metabolism and insulin sensitivity through activating AMPK pathway in non-alcoholic fatty liver disease. Life Sciences, 256, 117997.

Zhang, L., Li, W., Cao, L., Xu, J., Qian, Y., Chen, H., ... & Yu, J. (2019). PKNOX2 suppresses gastric cancer through the transcriptional activation of IGFBP5 and p53. Oncogene, 38(23), 4590-4604.

Aizawa, C., Saito, K., & Ohshima, H. (2019). Regulation of IGF-I by IGFBP3 and IGFBP5 during odontoblast differentiation in mice. Journal of Oral Biosciences, 61(3), 157-162.

Xu, S., Xu, Y., Yin, M., Zhang, S., Liu, P., Koroleva, M., ... & Jin, Z. G. (2018). Flow-dependent epigenetic regulation of IGFBP5 expression by H3K27me3 contributes to endothelial anti-inflammatory effects. Theranostics, 8(11), 3007.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Canine Recombinant IGFBP5 protein, hFc Tag (CAT#: V2LY-0526-LY1262)

Human Recombinant IGFBP5 protein, His Tag (CAT#: V2LY-0526-LY4671)

Rat Igfbp5 ELISA Kit (CAT#: V2LY-0626-LY1709)

Mouse Igfbp5 ELISA Kit (CAT#: V2LY-0626-LY1714)

Human IGFBP5 ELISA Kit (CAT#: V2LY-0626-LY2420)

Cattle IGFBP5 ELISA Kit (CAT#: V2LY-0626-LY2548)

Related Products

Rat Igfbp5 ELISA Kit (CAT#: V2LY-0626-LY1709)

Mouse Anti-IGFBP5 Recombinant Antibody (IBPF87) (CAT#: CBMAB-A4474-YC)

Mouse Anti-IGFBP5 Recombinant Antibody (CBYY-I1283) (CAT#: CBMAB-I2452-YY)

Cattle IGFBP5 ELISA Kit (CAT#: V2LY-0626-LY2548)

Mouse Anti-IGFBP5 Recombinant Antibody (A439) (CAT#: CBMAB-AP3827LY)

Mouse Anti-IGFBP5 Recombinant Antibody (CBYY-I1334) (CAT#: CBMAB-I2504-YY)

Canine Recombinant IGFBP5 protein, hFc Tag (CAT#: V2LY-0526-LY1262)

Human Recombinant IGFBP5 protein, His Tag (CAT#: V2LY-0526-LY4671)

Mouse Anti-IGFBP5 Recombinant Antibody (IBPF20) (CAT#: CBMAB-A4473-YC)

Human IGFBP5 ELISA Kit (CAT#: V2LY-0626-LY2420)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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