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Mouse Anti-IGFBP5 Recombinant Antibody (A439) (CBMAB-AP3827LY)

The product is antibody recognizes IGFBP5. The antibody A439 immunoassay techniques such as: ICC, IHC, IP, WB.
See all IGFBP5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
A439
Antibody Isotype
IgG
Application
ICC, IHC, IP, WB

Basic Information

Immunogen
Recombinant Insulin Like Growth Factor Binding Protein 5 (IGFBP5)
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Insulin Like Growth Factor Binding Protein 5
Introduction
IGFBP5 (Insulin Like Growth Factor Binding Protein 5) is a Protein Coding gene. Diseases associated with IGFBP5 include Insulin-Like Growth Factor I and Renal Osteodystrophy. Among its related pathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include fibronectin binding and insulin-like growth factor I binding. An important paralog of this gene is IGFBP3.
Entrez Gene ID
3488
UniProt ID
P24593
Alternative Names
Insulin Like Growth Factor Binding Protein 5
Function
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Biological Process
Aging Source: Ensembl
Cellular response to cAMP Source: UniProtKB
Cellular response to organic cyclic compound Source: UniProtKB
Female pregnancy Source: Ensembl
Glucose homeostasis Source: Ensembl
Hair follicle morphogenesis Source: Ensembl
Intracellular signal transduction Source: Ensembl
Lung alveolus development Source: Ensembl
Mammary gland involution Source: Ensembl
Negative regulation of cell migration Source: BHF-UCL
Negative regulation of growth Source: Ensembl
Negative regulation of insulin-like growth factor receptor signaling pathway Source: BHF-UCL
Negative regulation of muscle tissue development Source: Ensembl
Negative regulation of osteoblast differentiation Source: Ensembl
Negative regulation of skeletal muscle hypertrophy Source: Ensembl
Negative regulation of smooth muscle cell migration Source: BHF-UCL
Negative regulation of smooth muscle cell proliferation Source: BHF-UCL
Negative regulation of translation Source: BHF-UCL
Osteoblast differentiation Source: Ensembl
Positive regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
Positive regulation of protein kinase B signaling Source: Ensembl
Positive regulation of vascular associated smooth muscle cell migration Source: BHF-UCL
Positive regulation of vascular associated smooth muscle cell proliferation Source: BHF-UCL
Regulation of cell growth Source: Ensembl
Regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
Response to growth hormone Source: AgBase
Signal transduction Source: ProtInc
Striated muscle cell differentiation Source: Ensembl
Type B pancreatic cell proliferation Source: Ensembl
Cellular Location
Secreted

Uzuncakmak, S. K., Aksakal, A., Kerget, F., Aydın, P., & Halıcı, Z. (2023). Evaluation of IGFBP5 expression and plasma osteopontin level in COVID-19 patients. Advances in Medical Sciences, 68(1), 31-37.

Dittmer, J. (2022). Biological effects and regulation of IGFBP5 in breast cancer. Frontiers in Endocrinology, 13, 983793.

Song, C., Wang, S., Fu, Z., Chi, K., Geng, X., Liu, C., ... & Hong, Q. (2022). IGFBP5 promotes diabetic kidney disease progression by enhancing PFKFB3-mediated endothelial glycolysis. Cell Death & Disease, 13(4), 340.

Hao, J., Yang, H., Cao, Y., Zhang, C., & Fan, Z. (2020). IGFBP5 enhances the dentinogenesis potential of dental pulp stem cells via JNK and ErK signalling pathways. Journal of Oral Rehabilitation, 47(12), 1557-1565.

Ji, Y., Zhang, W., Yang, J., & Li, C. (2020). MiR-193b inhibits autophagy and apoptosis by targeting IGFBP5 in high glucose-induced trophoblasts. Placenta, 101, 185-193.

Dong, C., Zhang, J., Fang, S., & Liu, F. (2020). IGFBP5 increases cell invasion and inhibits cell proliferation by EMT and Akt signaling pathway in Glioblastoma multiforme cells. Cell division, 15(1), 1-9.

Xiao, Z., Chu, Y., & Qin, W. (2020). IGFBP5 modulates lipid metabolism and insulin sensitivity through activating AMPK pathway in non-alcoholic fatty liver disease. Life Sciences, 256, 117997.

Zhang, L., Li, W., Cao, L., Xu, J., Qian, Y., Chen, H., ... & Yu, J. (2019). PKNOX2 suppresses gastric cancer through the transcriptional activation of IGFBP5 and p53. Oncogene, 38(23), 4590-4604.

Aizawa, C., Saito, K., & Ohshima, H. (2019). Regulation of IGF-I by IGFBP3 and IGFBP5 during odontoblast differentiation in mice. Journal of Oral Biosciences, 61(3), 157-162.

Xu, S., Xu, Y., Yin, M., Zhang, S., Liu, P., Koroleva, M., ... & Jin, Z. G. (2018). Flow-dependent epigenetic regulation of IGFBP5 expression by H3K27me3 contributes to endothelial anti-inflammatory effects. Theranostics, 8(11), 3007.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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