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IGLL1

The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Full Name
Immunoglobulin Lambda Like Polypeptide 1
Function
Critical for B-cell development.
Biological Process
B cell receptor signaling pathway Source: GO_Central
Complement activation, classical pathway Source: GO_Central
Defense response to bacterium Source: GO_Central
Immune response Source: UniProtKB
Innate immune response Source: GO_Central
Phagocytosis, engulfment Source: GO_Central
Phagocytosis, recognition Source: GO_Central
Positive regulation of B cell activation Source: GO_Central
Cellular Location
Endoplasmic reticulum; Secreted. In pre-B cells, localizes predominantly to the endoplasmic reticulum.
Involvement in disease
Agammaglobulinemia 2, autosomal recessive (AGM2):
A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
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Anti-IGLL1 antibodies

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Rabbit Anti-IGLL1 Recombinant Antibody (EG1620) (CBMAB-EN1938-LY)

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Target: IGLL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1620
Application*: IHC: 1:50~1:100 ELISA: 1:40000
Datasheet SDS

Mouse Anti-IGLL1 Recombinant Antibody (A442) (CBMAB-AP3688LY)

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Target: IGLL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A442
Application*: Dot blot, ELISA, WB
Datasheet SDS

Mouse Anti-IGLL1 Recombinant Antibody (CBWJC-3801) (CBMAB-C5070WJ)

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Target: IGLL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-3801
Application*: F, IP, IH
Datasheet SDS

Rat Anti-IGLL1 Recombinant Antibody (CBWJC-2188) (CBMAB-C2962WJ)

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Target: IGLL1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBWJC-2188
Application*: F
Datasheet SDS

Mouse Anti-IGLL1 Recombinant Antibody (AT1G4) (CBMAB-I1924-YY)

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Target: IGLL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: AT1G4
Application*: E, WB
Datasheet SDS

Mouse Anti-IGLL1 Recombinant Antibody (CBYY-I0842) (CBMAB-I1923-YY)

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Target: IGLL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYY-I0842
Application*: WB
Datasheet SDS

Mouse Anti-IGLL1 Recombinant Antibody (CBYY-I0114) (CBMAB-I0329-YY)

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Target: IGLL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I0114
Application*: E, F
Datasheet SDS

Mouse Anti-IGLL1 Recombinant Antibody (CBYJL-064) (CBMAB-L0116-YJ)

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Target: IGLL1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYJL-064
Application*: WB, IP, IF, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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