Mouse Anti-IGLL1 Recombinant Antibody (CBWJC-3801) (CBMAB-C5070WJ)

Name: Mouse Anti-IGLL1 Recombinant Antibody (CBWJC-3801)
SKU: CBMAB-C5070WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJC-3801

Application

FC, IP, IHC

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Preservative

0.09% sodium azide

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Immunoglobulin Lambda Like Polypeptide 1

Introduction

The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Entrez Gene ID

3543

UniProt ID

P15814

Alternative Names

Immunoglobulin Lambda Like Polypeptide 1

Function

Critical for B-cell development.

Biological Process

B cell receptor signaling pathway Source: GO_Central
Complement activation, classical pathway Source: GO_Central
Defense response to bacterium Source: GO_Central
Immune response Source: UniProtKB
Innate immune response Source: GO_Central
Phagocytosis, engulfment Source: GO_Central
Phagocytosis, recognition Source: GO_Central
Positive regulation of B cell activation Source: GO_Central

Cellular Location

Endoplasmic reticulum; Secreted. In pre-B cells, localizes predominantly to the endoplasmic reticulum.

Involvement in disease

Agammaglobulinemia 2, autosomal recessive (AGM2):
A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.

Wu, S. Y., Chu, X. R., Ji, Q., Lin, X. C., Bai, Z. J., Li, J. Q., ... & Hu, S. Y. (2023). Expression of IGLL1 Gene and Its Clinical Significance in Pediatric T-ALL. Zhongguo shi yan xue ye xue za zhi, 31(4), 999-1004.

Wang, Y., Wang, S., Jing, H., Zhang, T., Song, N., & Xu, S. (2022). CircRNA-IGLL1/miR-15a/RNF43 axis mediates ammonia-induced autophagy in broilers jejunum via Wnt/β-catenin pathway. Environmental Pollution, 292, 118332.

Rouzet, A., Morell, F., Reboux, G., Villar, A., Millon, L., & Cruz, M. J. (2022). Pilot study using recombinant antigens r-PROE and r-IGLL1 for the serodiagnosis of feather duvet lung. Archivos de bronconeumologia, 58(7), 554-560.

Rouzet, A., Scherer, E., Barrera, C., Gondouin, A., Reboux, G., Humbert, K., ... & Bellanger, A. P. (2022). Bird fancier's lung serodiagnosis by automated r-IgLL1 ELISA. Journal of Immunological Methods, 505, 113267.

Rouzet, A., Morell, F., REBOUX, G., Villar, A., Millon, L., & Cruz, M. J. (2020). Recombinant antigens r-PROE and r-IGLL1 for serodiagnosis of feather duvet lung. Authorea Preprints.

Cosgun, K. N., Hendriks, R. W., Dickins, R. A., Heisterkamp, N., & Muschen, M. (2018). Pre-BCR Surrogate Light Chain Components VPREB1 and IGLL1 Function As Pre-BCR-Independent Tumor Suppressors in Acute Lymphoblastic Leukemia. Blood, 132, 570.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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