IL22RA1
The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008]
Full Name
Interleukin 22 Receptor Subunit Alpha 1
Function
Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.
Biological Process
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Defense response to Gram-negative bacteriumIEA:Ensembl
Defense response to Gram-negative bacteriumIEA:Ensembl
Cellular Location
Membrane
Topology
Extracellular: 16-228
Helical: 229-249
Cytoplasmic: 250-574
Helical: 229-249
Cytoplasmic: 250-574
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Anti-IL22RA1 antibodies
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CompareTarget: IL22RA1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E6
Application*: WB, E
Target: IL22RA1
Sensitivity: 0.016 ng/mL
Detection Range: 0.03-9 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: IL22RA1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-228
Tag: His Tag
Target: IL22RA1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-228
Tag: hFc Tag
Target: IL22RA1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 16-228
Tag: His Tag
Target: IL22RA1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 16-228
Tag: His Tag
Target: IL22RA1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-226
Tag: His Tag
Target: IL22RA1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-226
Tag: hFc Tag
Target: IL22RA1
Specificity: Human
Target: IL22RA1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 6B5
Application*: E, WB
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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