Mouse Anti-IL22RA1 Recombinant Antibody (2E6) (CBMAB-A4391-LY)

The product is antibody recognizes IL22RA1. The antibody 2E6 immunoassay techniques such as: WB, ELISA.
See all IL22RA1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

2E6

Antibody Isotype

IgG2a, κ

Application

WB, ELISA

Basic Information

Immunogen

IL22RA1 (NP_067081, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Interleukin 22 Receptor Subunit Alpha 1

Introduction

The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq]

Entrez Gene ID

58985

UniProt ID

Q8N6P7

Alternative Names

CRF2-9; IL22R; IL22R1

Function

Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.

Biological Process

Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Defense response to Gram-negative bacteriumIEA:Ensembl

Cellular Location

Membrane

Topology

Extracellular: 16-228
Helical: 229-249
Cytoplasmic: 250-574

References

Tang, W., Lu, Q., Zhu, J., Zheng, X., Fang, N., Ji, S., & Lu, F. (2022). Identification of a prognostic signature composed of GPI, IL22RA1, CCT6A and SPOCK1 for lung adenocarcinoma based on Bioinformatic analysis of lncRNA-mediated ceRNA network and sample validation. Frontiers in Oncology, 12, 844691.

de Brito, R. J. V. C., do Carmo, R. F., Silva, B. M. S., Barbosa Júnior, W. L., Vasconcelos, L. R. S., Pereira, L. M. M. B., & Moura, P. (2022). Lack of Association of Polymorphisms in IL22 and IL22RA1 Genes with Fibrosis Severity in Patients with Chronic Hepatitis C. Viral Immunology, 35(7), 509-513.

Zhang, S., & Yang, G. (2022). IL22RA1/JAK/STAT Signaling Acts As a Cancer Target Through Pan-Cancer Analysis. Frontiers in Immunology, 13, 915246.

Zhao, Y., Zhang, F., Pan, Z., Luo, H., Liu, K., & Duan, X. (2019). LncRNA NR_003923 promotes cell proliferation, migration, fibrosis, and autophagy via the miR-760/miR-215-3p/IL22RA1 axis in human Tenon’s capsule fibroblasts. Cell Death & Disease, 10(8), 594.

Cui, X., Jing, X., Yi, Q., Xiang, Z., Tian, J., Tan, B., & Zhu, J. (2019). IL22 furthers malignant transformation of rat mesenchymal stem cells, possibly in association with IL22RA1/STAT3 signaling. Oncology reports, 41(4), 2148-2158.

He, W., Wu, J., Shi, J., Huo, Y. M., Dai, W., Geng, J., ... & Xue, J. (2018). IL22RA1/STAT3 signaling promotes stemness and tumorigenicity in pancreatic cancer. Cancer research, 78(12), 3293-3305.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Antibody Pairs

IL22RA1 Matched Antibody Pair (632)

Related Products

Mouse Anti-IL22RA1 Recombinant Antibody (6B5)

IL22RA1 Matched Antibody Pair (632)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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