Canine Recombinant IL22RA1 protein, hFc Tag (V2LY-0526-LY1280)

Name: Canine Recombinant IL22RA1 protein, hFc Tag
SKU: V2LY-0526-LY1280
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Canine

Tag

hFc Tag

Protein Construction

This product is Canine Recombinant IL22RA1 protein, hFc Tag consist of Amino Acid: 1-226 and predicts a molecular mass of 51.2 kDa.

Molecule Mass

51.2 kDa

Sequence

Amino Acid: 1-226

Species

Canine

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>85% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Interleukin 22 Receptor Subunit Alpha 1

Function

Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.

Biological Process

Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Defense response to Gram-negative bacteriumIEA:Ensembl

Cellular Location

Membrane

Topology

Extracellular: 16-228
Helical: 229-249
Cytoplasmic: 250-574

Tang, W., Lu, Q., Zhu, J., Zheng, X., Fang, N., Ji, S., & Lu, F. (2022). Identification of a prognostic signature composed of GPI, IL22RA1, CCT6A and SPOCK1 for lung adenocarcinoma based on Bioinformatic analysis of lncRNA-mediated ceRNA network and sample validation. Frontiers in Oncology, 12, 844691.

de Brito, R. J. V. C., do Carmo, R. F., Silva, B. M. S., Barbosa Júnior, W. L., Vasconcelos, L. R. S., Pereira, L. M. M. B., & Moura, P. (2022). Lack of Association of Polymorphisms in IL22 and IL22RA1 Genes with Fibrosis Severity in Patients with Chronic Hepatitis C. Viral Immunology, 35(7), 509-513.

Zhang, S., & Yang, G. (2022). IL22RA1/JAK/STAT Signaling Acts As a Cancer Target Through Pan-Cancer Analysis. Frontiers in Immunology, 13, 915246.

Zhao, Y., Zhang, F., Pan, Z., Luo, H., Liu, K., & Duan, X. (2019). LncRNA NR_003923 promotes cell proliferation, migration, fibrosis, and autophagy via the miR-760/miR-215-3p/IL22RA1 axis in human Tenon’s capsule fibroblasts. Cell Death & Disease, 10(8), 594.

Cui, X., Jing, X., Yi, Q., Xiang, Z., Tian, J., Tan, B., & Zhu, J. (2019). IL22 furthers malignant transformation of rat mesenchymal stem cells, possibly in association with IL22RA1/STAT3 signaling. Oncology reports, 41(4), 2148-2158.

He, W., Wu, J., Shi, J., Huo, Y. M., Dai, W., Geng, J., ... & Xue, J. (2018). IL22RA1/STAT3 signaling promotes stemness and tumorigenicity in pancreatic cancer. Cancer research, 78(12), 3293-3305.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Canine Recombinant IL22RA1 protein, His Tag (CAT#: V2LY-0526-LY1281)

Human Recombinant IL22RA1 protein, His Tag (CAT#: V2LY-0526-LY4848)

Human Recombinant IL22RA1 protein, His Tag-1 (CAT#: V2LY-0526-LY4849)

Rat Recombinant IL22RA1 protein, ECD, hFc Tag (CAT#: V2LY-0526-LY9462)

Rat Recombinant IL22RA1 protein, ECD, His Tag (CAT#: V2LY-0526-LY9463)

Human IL22RA1 ELISA Kit (CAT#: V2LY-0626-LY4763)

IL22RA1 Matched Antibody Pair (632) (CAT#: APMAB-632LY)

Antibody Pairs

IL22RA1 Matched Antibody Pair (632) (CAT#: APMAB-632LY)

Related Products

IL22RA1 Matched Antibody Pair (632) (CAT#: APMAB-632LY)

Mouse Anti-IL22RA1 Recombinant Antibody (6B5) (CAT#: CBMAB-I1549-YY)

Rat Recombinant IL22RA1 protein, ECD, His Tag (CAT#: V2LY-0526-LY9463)

Human IL22RA1 ELISA Kit (CAT#: V2LY-0626-LY4763)

Human Recombinant IL22RA1 protein, His Tag (CAT#: V2LY-0526-LY4848)

Mouse Anti-IL22RA1 Recombinant Antibody (2E6) (CAT#: CBMAB-A4391-LY)

Human Recombinant IL22RA1 protein, His Tag-1 (CAT#: V2LY-0526-LY4849)

Rat Recombinant IL22RA1 protein, ECD, hFc Tag (CAT#: V2LY-0526-LY9462)

Canine Recombinant IL22RA1 protein, His Tag (CAT#: V2LY-0526-LY1281)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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